A dsRNA virus with filamentous viral particles

Viruses with double-stranded RNA genomes form isometric particles or are capsidless. Here we report a double-stranded RNA virus, Colletotrichum camelliae filamentous virus 1 (CcFV-1) isolated from a fungal pathogen, that forms filamentous particles. CcFV-1 has eight genomic double-stranded RNAs, ran...

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Veröffentlicht in:Nature communications Jg. 8; H. 1; S. 168 - 12
Hauptverfasser: Jia, Hengxia, Dong, Kaili, Zhou, Lingling, Wang, Guoping, Hong, Ni, Jiang, Daohong, Xu, Wenxing
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.08.2017
Nature Publishing Group
Nature Portfolio
Schlagworte:
631/326/596/2148
631/326/596/2554
Capsid Proteins - genetics
Colletotrichum - virology
Double-stranded RNA
Fungal Viruses - genetics
Fungal Viruses - isolation & purification
Genomes
Humanities and Social Sciences
Isometric
multidisciplinary
Open Reading Frames - genetics
Ribonucleic acid
RNA
RNA polymerase
RNA Replicase - genetics
RNA viruses
RNA Viruses - genetics
RNA Viruses - isolation & purification
RNA, Double-Stranded - genetics
Science
Science (multidisciplinary)
Virion
Viruses
ISSN:2041-1723, 2041-1723
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Zusammenfassung:Viruses with double-stranded RNA genomes form isometric particles or are capsidless. Here we report a double-stranded RNA virus, Colletotrichum camelliae filamentous virus 1 (CcFV-1) isolated from a fungal pathogen, that forms filamentous particles. CcFV-1 has eight genomic double-stranded RNAs, ranging from 990 to 2444 bp, encoding 10 putative open reading frames, of which open reading frame 1 encodes an RNA-dependent RNA polymerase and open reading frame 4 a capsid protein. When inoculated, the naked CcFV-1 double-stranded RNAs are infectious and induce the accumulation of the filamentous particles in vivo. CcFV-1 is phylogenetically related to Aspergillus fumigatus tetramycovirus-1 and Beauveria bassiana polymycovirus-1, but differs in morphology and in the number of genomic components. CcFV-1 might be an intermediate virus related to truly capsidated viruses, or might represent a distinct encapsidating strategy. In terms of genome and particle architecture, our findings are a significant addition to the knowledge of the virosphere diversity. Viruses with double-stranded RNA (dsRNA) genomes form typically isometric particles or are capsid-less. Here, the authors identify a mycovirus with an eight-segmented dsRNA genome that forms exceptionally long filamentous particles and could represent an evolutionary link between ssRNA and dsRNA viruses.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-017-00237-9