Particular matter influences the incidence of acute otitis media in children

Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most common diseases in children. However, studies on the relationship between AOM in children and PM are rare and their results are inconsistent. The aim o...

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Published in:	Scientific reports Vol. 11; no. 1; pp. 19730 - 9
Main Authors:	Park, Mina, Han, Jiyeon, Park, Jiwon, Jang, Myoung-jin, Park, Moo Kyun
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.10.2021 Nature Publishing Group Nature Portfolio
Subjects:	692/308 692/499 692/699 704/172 704/844 Acute Disease Age Factors Age groups Air Pollutants Air Pollution Antibiotics Child Child, Preschool Children Disease Susceptibility Ear diseases Environmental Exposure Environmental research Exposure Female Humanities and Social Sciences Humans Incidence Infant Infant, Newborn Male multidisciplinary Otitis media Otitis Media - epidemiology Otitis Media - etiology Particle Size Particulate matter Particulate Matter - adverse effects Public Health Surveillance Republic of Korea - epidemiology Risk Factors Science Science (multidisciplinary) Seasons Republic of Korea
ISSN:	2045-2322, 2045-2322
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Abstract	Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most common diseases in children. However, studies on the relationship between AOM in children and PM are rare and their results are inconsistent. The aim of this study is to investigate the effect of PM on AOM in children on the basis of the Korea National Health Insurance service (NHIS) claims data. NHIS claim data from 2008 to 2015 was used to identify outpatient visits, antibiotic use to treat AOM, and demographic data. This data was combined with the data on PM 2.5 (≤ 2.5 μm) and PM 10 (≤ 10 μm according to its aerodynamic diameter) level extracted from air pollution data from Korean National Institute of Environmental Research for 16 administrative regions. The children with AOM were divided into three age groups (< 2, 2–4, 5–10 years). Generalized linear Poisson regression model was used to estimate the association between AOM and PM using daily counts of AOM and daily mean PM concentrations. It was adjusted to temperature, wind, humidity, season, year, age, and region. With an increase in PM 2.5 of 10 μg/m 3 , the relative risk of OM increased by 4.5% in children under 2 years of age. The effect of PM 2.5 was strongest influence on the day of exposure. The exposure to PM 10 was related to the incidence of AOM on the day of exposure and the following seven days in all three age groups. The PM concentrations did not strongly affect either AOM duration or the use of antibiotics to cure AOM. The RR in the each lag day after exposure to PM 10 was diverse according to the age groups. Regardless of PM size and children’s age, the PM levels are positively related to the incidence of AOM. Both PM 2.5 and PM 10 have the most adverse effects on children under 2 years of age and on the day of exposure.
AbstractList	Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most common diseases in children. However, studies on the relationship between AOM in children and PM are rare and their results are inconsistent. The aim of this study is to investigate the effect of PM on AOM in children on the basis of the Korea National Health Insurance service (NHIS) claims data. NHIS claim data from 2008 to 2015 was used to identify outpatient visits, antibiotic use to treat AOM, and demographic data. This data was combined with the data on PM 2.5 (≤ 2.5 μm) and PM 10 (≤ 10 μm according to its aerodynamic diameter) level extracted from air pollution data from Korean National Institute of Environmental Research for 16 administrative regions. The children with AOM were divided into three age groups (< 2, 2–4, 5–10 years). Generalized linear Poisson regression model was used to estimate the association between AOM and PM using daily counts of AOM and daily mean PM concentrations. It was adjusted to temperature, wind, humidity, season, year, age, and region. With an increase in PM 2.5 of 10 μg/m 3 , the relative risk of OM increased by 4.5% in children under 2 years of age. The effect of PM 2.5 was strongest influence on the day of exposure. The exposure to PM 10 was related to the incidence of AOM on the day of exposure and the following seven days in all three age groups. The PM concentrations did not strongly affect either AOM duration or the use of antibiotics to cure AOM. The RR in the each lag day after exposure to PM 10 was diverse according to the age groups. Regardless of PM size and children’s age, the PM levels are positively related to the incidence of AOM. Both PM 2.5 and PM 10 have the most adverse effects on children under 2 years of age and on the day of exposure. Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most common diseases in children. However, studies on the relationship between AOM in children and PM are rare and their results are inconsistent. The aim of this study is to investigate the effect of PM on AOM in children on the basis of the Korea National Health Insurance service (NHIS) claims data. NHIS claim data from 2008 to 2015 was used to identify outpatient visits, antibiotic use to treat AOM, and demographic data. This data was combined with the data on PM (≤ 2.5 μm) and PM (≤ 10 μm according to its aerodynamic diameter) level extracted from air pollution data from Korean National Institute of Environmental Research for 16 administrative regions. The children with AOM were divided into three age groups (< 2, 2-4, 5-10 years). Generalized linear Poisson regression model was used to estimate the association between AOM and PM using daily counts of AOM and daily mean PM concentrations. It was adjusted to temperature, wind, humidity, season, year, age, and region. With an increase in PM of 10 μg/m , the relative risk of OM increased by 4.5% in children under 2 years of age. The effect of PM was strongest influence on the day of exposure. The exposure to PM was related to the incidence of AOM on the day of exposure and the following seven days in all three age groups. The PM concentrations did not strongly affect either AOM duration or the use of antibiotics to cure AOM. The RR in the each lag day after exposure to PM was diverse according to the age groups. Regardless of PM size and children's age, the PM levels are positively related to the incidence of AOM. Both PM and PM have the most adverse effects on children under 2 years of age and on the day of exposure. Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most common diseases in children. However, studies on the relationship between AOM in children and PM are rare and their results are inconsistent. The aim of this study is to investigate the effect of PM on AOM in children on the basis of the Korea National Health Insurance service (NHIS) claims data. NHIS claim data from 2008 to 2015 was used to identify outpatient visits, antibiotic use to treat AOM, and demographic data. This data was combined with the data on PM2.5 (≤ 2.5 μm) and PM10 (≤ 10 μm according to its aerodynamic diameter) level extracted from air pollution data from Korean National Institute of Environmental Research for 16 administrative regions. The children with AOM were divided into three age groups (< 2, 2–4, 5–10 years). Generalized linear Poisson regression model was used to estimate the association between AOM and PM using daily counts of AOM and daily mean PM concentrations. It was adjusted to temperature, wind, humidity, season, year, age, and region. With an increase in PM2.5 of 10 μg/m3, the relative risk of OM increased by 4.5% in children under 2 years of age. The effect of PM2.5 was strongest influence on the day of exposure. The exposure to PM10 was related to the incidence of AOM on the day of exposure and the following seven days in all three age groups. The PM concentrations did not strongly affect either AOM duration or the use of antibiotics to cure AOM. The RR in the each lag day after exposure to PM10 was diverse according to the age groups. Regardless of PM size and children’s age, the PM levels are positively related to the incidence of AOM. Both PM2.5 and PM10 have the most adverse effects on children under 2 years of age and on the day of exposure. Abstract Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most common diseases in children. However, studies on the relationship between AOM in children and PM are rare and their results are inconsistent. The aim of this study is to investigate the effect of PM on AOM in children on the basis of the Korea National Health Insurance service (NHIS) claims data. NHIS claim data from 2008 to 2015 was used to identify outpatient visits, antibiotic use to treat AOM, and demographic data. This data was combined with the data on PM2.5 (≤ 2.5 μm) and PM10 (≤ 10 μm according to its aerodynamic diameter) level extracted from air pollution data from Korean National Institute of Environmental Research for 16 administrative regions. The children with AOM were divided into three age groups (< 2, 2–4, 5–10 years). Generalized linear Poisson regression model was used to estimate the association between AOM and PM using daily counts of AOM and daily mean PM concentrations. It was adjusted to temperature, wind, humidity, season, year, age, and region. With an increase in PM2.5 of 10 μg/m3, the relative risk of OM increased by 4.5% in children under 2 years of age. The effect of PM2.5 was strongest influence on the day of exposure. The exposure to PM10 was related to the incidence of AOM on the day of exposure and the following seven days in all three age groups. The PM concentrations did not strongly affect either AOM duration or the use of antibiotics to cure AOM. The RR in the each lag day after exposure to PM10 was diverse according to the age groups. Regardless of PM size and children’s age, the PM levels are positively related to the incidence of AOM. Both PM2.5 and PM10 have the most adverse effects on children under 2 years of age and on the day of exposure. Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most common diseases in children. However, studies on the relationship between AOM in children and PM are rare and their results are inconsistent. The aim of this study is to investigate the effect of PM on AOM in children on the basis of the Korea National Health Insurance service (NHIS) claims data. NHIS claim data from 2008 to 2015 was used to identify outpatient visits, antibiotic use to treat AOM, and demographic data. This data was combined with the data on PM2.5 (≤ 2.5 μm) and PM10 (≤ 10 μm according to its aerodynamic diameter) level extracted from air pollution data from Korean National Institute of Environmental Research for 16 administrative regions. The children with AOM were divided into three age groups (< 2, 2–4, 5–10 years). Generalized linear Poisson regression model was used to estimate the association between AOM and PM using daily counts of AOM and daily mean PM concentrations. It was adjusted to temperature, wind, humidity, season, year, age, and region. With an increase in PM2.5 of 10 μg/m3, the relative risk of OM increased by 4.5% in children under 2 years of age. The effect of PM2.5 was strongest influence on the day of exposure. The exposure to PM10 was related to the incidence of AOM on the day of exposure and the following seven days in all three age groups. The PM concentrations did not strongly affect either AOM duration or the use of antibiotics to cure AOM. The RR in the each lag day after exposure to PM10 was diverse according to the age groups. Regardless of PM size and children’s age, the PM levels are positively related to the incidence of AOM. Both PM2.5 and PM10 have the most adverse effects on children under 2 years of age and on the day of exposure. Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most common diseases in children. However, studies on the relationship between AOM in children and PM are rare and their results are inconsistent. The aim of this study is to investigate the effect of PM on AOM in children on the basis of the Korea National Health Insurance service (NHIS) claims data. NHIS claim data from 2008 to 2015 was used to identify outpatient visits, antibiotic use to treat AOM, and demographic data. This data was combined with the data on PM2.5 (≤ 2.5 μm) and PM10 (≤ 10 μm according to its aerodynamic diameter) level extracted from air pollution data from Korean National Institute of Environmental Research for 16 administrative regions. The children with AOM were divided into three age groups (< 2, 2-4, 5-10 years). Generalized linear Poisson regression model was used to estimate the association between AOM and PM using daily counts of AOM and daily mean PM concentrations. It was adjusted to temperature, wind, humidity, season, year, age, and region. With an increase in PM2.5 of 10 μg/m3, the relative risk of OM increased by 4.5% in children under 2 years of age. The effect of PM2.5 was strongest influence on the day of exposure. The exposure to PM10 was related to the incidence of AOM on the day of exposure and the following seven days in all three age groups. The PM concentrations did not strongly affect either AOM duration or the use of antibiotics to cure AOM. The RR in the each lag day after exposure to PM10 was diverse according to the age groups. Regardless of PM size and children's age, the PM levels are positively related to the incidence of AOM. Both PM2.5 and PM10 have the most adverse effects on children under 2 years of age and on the day of exposure.Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most common diseases in children. However, studies on the relationship between AOM in children and PM are rare and their results are inconsistent. The aim of this study is to investigate the effect of PM on AOM in children on the basis of the Korea National Health Insurance service (NHIS) claims data. NHIS claim data from 2008 to 2015 was used to identify outpatient visits, antibiotic use to treat AOM, and demographic data. This data was combined with the data on PM2.5 (≤ 2.5 μm) and PM10 (≤ 10 μm according to its aerodynamic diameter) level extracted from air pollution data from Korean National Institute of Environmental Research for 16 administrative regions. The children with AOM were divided into three age groups (< 2, 2-4, 5-10 years). Generalized linear Poisson regression model was used to estimate the association between AOM and PM using daily counts of AOM and daily mean PM concentrations. It was adjusted to temperature, wind, humidity, season, year, age, and region. With an increase in PM2.5 of 10 μg/m3, the relative risk of OM increased by 4.5% in children under 2 years of age. The effect of PM2.5 was strongest influence on the day of exposure. The exposure to PM10 was related to the incidence of AOM on the day of exposure and the following seven days in all three age groups. The PM concentrations did not strongly affect either AOM duration or the use of antibiotics to cure AOM. The RR in the each lag day after exposure to PM10 was diverse according to the age groups. Regardless of PM size and children's age, the PM levels are positively related to the incidence of AOM. Both PM2.5 and PM10 have the most adverse effects on children under 2 years of age and on the day of exposure.
ArticleNumber	19730
Author	Park, Mina Jang, Myoung-jin Park, Moo Kyun Han, Jiyeon Park, Jiwon
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Cites_doi	10.1016/j.ijporl.2011.12.003 10.1177/00034894800890S308 10.3389/fpubh.2020.00014 10.1001/jamapediatrics.2019.5664 10.1016/j.ijporl.2020.110002 10.1038/s41598-019-55956-4 10.1016/j.vaccine.2008.11.005 10.1056/NEJMoa1817364 10.1186/s12889-020-08503-0 10.1007/s00276-016-1786-7 10.1038/s41370-017-0006-9 10.1016/S0165-5876(98)00159-1 10.1016/S1198-743X(14)64947-8 10.1080/00016489950181963 10.1080/10590500802494538 10.3109/00016488109133287 10.1073/pnas.1803222115 10.3390/ijerph15020257 10.1016/j.envres.2018.07.008 10.1186/s12940-016-0196-y 10.1371/journal.pone.0199296 10.1016/S0196-0709(86)80034-5 10.1590/S1807-59322011000300005 10.1177/0194599814525576 10.1111/jnu.12195 10.4093/dmj.2014.38.5.395 10.4070/kcj.2020.0171 10.1542/peds.2012-3488 10.1371/journal.pone.0166044 10.1111/j.1440-1681.2006.04357.x 10.1016/j.envint.2014.10.005 10.1097/MOP.0000000000000184 10.1289/ehp.0901675 10.1016/j.ijporl.2014.10.011 10.1093/infdis/160.1.83 10.21101/cejph.a3950 10.3346/jkms.2012.27.8.835 10.1093/aje/kwt090 10.1016/j.envint.2020.106133 10.1289/ehp.9089 10.1016/S1473-3099(15)00549-6 10.1056/NEJM200102083440602 10.1080/15287390701598234
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References	Oh (CR38) 2020; 145 Burnett (CR1) 2018; 115 Paul, Moreno (CR54) 2020; 174 Lieberthal (CR21) 2013; 131 Homøe, Christensen, Bretlau (CR45) 1999; 119 Pinkerton, Joad (CR32) 2006; 33 Klepac, Locatelli, Korošec, Künzli, Kukec (CR6) 2018; 167 Valavanidis, Fiotakis, Vlachogianni (CR7) 2008; 26 Dostál, Průcha, Rychlíková, Pastorková, Srám (CR15) 2014; 22 Lee (CR22) 2012; 27 Bateson, Schwartz (CR31) 2008; 71 Kim (CR8) 2020; 134 Wang, Chang, Chuang, Su, Li (CR41) 2011; 66 Manisalidis, Stavropoulou, Stavropoulos, Bezirtzoglou (CR3) 2020; 8 CR9 Kim (CR29) 2016; 11 Brauer (CR47) 2006; 114 Park (CR13) 2018; 13 Shahbaznejad (CR17) 2021; 2021 Bylander, Ivarsson, Tjernström (CR34) 1981; 92 Stangerup, Tos (CR43) 1986; 7 Paetz, Goetz, Lanfermann, Giesemann (CR35) 2017; 39 Kim (CR4) 2019; 9 Eskola (CR57) 2001; 344 Sakulchit, Goldman (CR51) 2017; 63 Shin (CR2) 2020; 20 Mutlu, Odabasi, Metin, Basak, Erpek (CR10) 1998; 46 Park, Chae, Kim, Cho, Song (CR28) 2014; 78 Terzano, Di Stefano, Conti, Graziani, Petroianni (CR50) 2010; 14 Song (CR20) 2014; 38 CR19 Bowatte (CR14) 2018; 15 Dagan, Pelton, Bakaletz, Cohen (CR56) 2016; 16 Nokso-Koivisto, Marom, Chonmaitree (CR16) 2015; 27 Zemek, Szyszkowicz, Rowe (CR48) 2010; 118 Burtscher, Schüepp (CR30) 2012; 13 CR53 Rovers (CR11) 2008; 26 Xiao (CR37) 2016; 15 Teele, Klein, Rosner (CR40) 1989; 160 Choi (CR55) 2020; 50 Bell, Zanobetti, Dominici (CR18) 2013; 178 Kim, Kabir, Kabir (CR5) 2015; 74 Bylander (CR33) 1980; 89 Kousha, Castner (CR36) 2016; 48 Bluestone, Klein, Bluestone (CR42) 2006 CR26 Lundgren, Ingvarsson (CR44) 1983; 39 Girguis (CR49) 2018; 28 Lee, Kim, Park, Kim (CR52) 2015; 58 CR25 CR24 Liu (CR46) 2019; 381 CR23 Song, Lee, Lee, Chae, Park (CR27) 2012; 76 Baraibar (CR39) 1997; 3 Grindler, Blank, Schulz, Witsell, Lieu (CR12) 2014; 151 M Brauer (99247_CR47) 2006; 114 MM Rovers (99247_CR11) 2008; 26 S-E Stangerup (99247_CR43) 1986; 7 C Terzano (99247_CR50) 2010; 14 T Kousha (99247_CR36) 2016; 48 CR Paul (99247_CR54) 2020; 174 R Dagan (99247_CR56) 2016; 16 MS Girguis (99247_CR49) 2018; 28 C Liu (99247_CR46) 2019; 381 DJ Grindler (99247_CR12) 2014; 151 J Eskola (99247_CR57) 2001; 344 P Klepac (99247_CR6) 2018; 167 J Nokso-Koivisto (99247_CR16) 2015; 27 P Paetz (99247_CR35) 2017; 39 SO Song (99247_CR20) 2014; 38 M Park (99247_CR13) 2018; 13 HJ Kim (99247_CR29) 2016; 11 R Zemek (99247_CR48) 2010; 118 PC Wang (99247_CR41) 2011; 66 Q Xiao (99247_CR37) 2016; 15 A Valavanidis (99247_CR7) 2008; 26 SY Kim (99247_CR4) 2019; 9 KH Kim (99247_CR5) 2015; 74 HJ Lee (99247_CR22) 2012; 27 99247_CR53 EK Choi (99247_CR55) 2020; 50 AS Lieberthal (99247_CR21) 2013; 131 M Dostál (99247_CR15) 2014; 22 R Baraibar (99247_CR39) 1997; 3 K Lundgren (99247_CR44) 1983; 39 99247_CR9 99247_CR19 A Bylander (99247_CR33) 1980; 89 DW Teele (99247_CR40) 1989; 160 99247_CR23 99247_CR24 TF Bateson (99247_CR31) 2008; 71 99247_CR25 99247_CR26 WY Shin (99247_CR2) 2020; 20 JJ Song (99247_CR27) 2012; 76 I Manisalidis (99247_CR3) 2020; 8 A Bylander (99247_CR34) 1981; 92 R Burnett (99247_CR1) 2018; 115 TH Kim (99247_CR8) 2020; 134 CD Bluestone (99247_CR42) 2006 C Mutlu (99247_CR10) 1998; 46 KE Pinkerton (99247_CR32) 2006; 33 ML Bell (99247_CR18) 2013; 178 T Sakulchit (99247_CR51) 2017; 63 L Shahbaznejad (99247_CR17) 2021; 2021 G Bowatte (99247_CR14) 2018; 15 J Oh (99247_CR38) 2020; 145 P Homøe (99247_CR45) 1999; 119 H Burtscher (99247_CR30) 2012; 13 MK Park (99247_CR28) 2014; 78 HJ Lee (99247_CR52) 2015; 58
References_xml	– volume: 76 start-page: 334 year: 2012 end-page: 338 ident: CR27 article-title: Effect of diesel exhaust particles on human middle ear epithelial cells publication-title: Int. J. Pediatr. Otorhinolaryngol. doi: 10.1016/j.ijporl.2011.12.003 – volume: 89 start-page: 20 year: 1980 end-page: 24 ident: CR33 article-title: Comparison of eustachian tube function in children and adults with normal ears publication-title: Ann. Otol. Rhinol. Laryngol. Suppl. doi: 10.1177/00034894800890S308 – volume: 8 start-page: 14 year: 2020 ident: CR3 article-title: Environmental and health impacts of air pollution: A review publication-title: Front. Public Health doi: 10.3389/fpubh.2020.00014 – volume: 174 start-page: 308 year: 2020 end-page: 308 ident: CR54 article-title: Acute otitis media publication-title: JAMA Pediatr. doi: 10.1001/jamapediatrics.2019.5664 – year: 2006 ident: CR42 publication-title: Otitis Media in Infants and Children – volume: 134 year: 2020 ident: CR8 article-title: The change of prevalence and recurrence of acute otitis media in Korea publication-title: Int. J. Pediatr. Otorhinolaryngol. doi: 10.1016/j.ijporl.2020.110002 – volume: 9 start-page: 19421 year: 2019 ident: CR4 article-title: Neuronal and perineuronal changes of cerebral cortex after exposure to inhaled particulate matter publication-title: Sci. Rep. doi: 10.1038/s41598-019-55956-4 – volume: 26 start-page: G2 issue: Suppl 7 year: 2008 end-page: G4 ident: CR11 article-title: The burden of otitis media publication-title: Vaccine doi: 10.1016/j.vaccine.2008.11.005 – volume: 381 start-page: 705 year: 2019 end-page: 715 ident: CR46 article-title: Ambient particulate air pollution and daily mortality in 652 cities publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1817364 – volume: 14 start-page: 809 year: 2010 end-page: 821 ident: CR50 article-title: Air pollution ultrafine particles: Toxicity beyond the lung publication-title: Eur. Rev. Med. Pharmacol. Sci. – volume: 20 start-page: 430 year: 2020 ident: CR2 article-title: Exposure to ambient fine particulate matter is associated with changes in fasting glucose and lipid profiles: A nationwide cohort study publication-title: BMC Public Health doi: 10.1186/s12889-020-08503-0 – volume: 39 start-page: 663 year: 2017 end-page: 671 ident: CR35 article-title: The developing temporal bone: Computed tomography measurements and assessment of suture closure from birth to 18 years of age publication-title: Surg. Radiol. Anat. doi: 10.1007/s00276-016-1786-7 – volume: 28 start-page: 348 year: 2018 end-page: 357 ident: CR49 article-title: Exposure to acute air pollution and risk of bronchiolitis and otitis media for preterm and term infants publication-title: J. Expo Sci. Environ. Epidemiol. doi: 10.1038/s41370-017-0006-9 – ident: CR25 – volume: 46 start-page: 179 year: 1998 end-page: 184 ident: CR10 article-title: Sensorineural hearing loss associated with otitis media with effusion in children publication-title: Int. J. Pediatr. Otorhinolaryngol. doi: 10.1016/S0165-5876(98)00159-1 – volume: 3 start-page: 3S13 year: 1997 end-page: 13S22 ident: CR39 article-title: Incidence and risk factors of acute otitis media in children publication-title: Clin. Microbiol. Infect. doi: 10.1016/S1198-743X(14)64947-8 – volume: 2021 year: 2021 ident: CR17 article-title: Comparing watchful waiting approach vs. antibiotic therapy in children with nonsevere acute otitis media: A randomized clinical trial publication-title: Int. J. Pediatr. – ident: CR19 – volume: 119 start-page: 65 year: 1999 end-page: 71 ident: CR45 article-title: Acute otitis media and age at onset among children in Greenland publication-title: Acta Otolaryngol. doi: 10.1080/00016489950181963 – volume: 26 start-page: 339 year: 2008 end-page: 362 ident: CR7 article-title: Airborne particulate matter and human health: Toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms publication-title: J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. doi: 10.1080/10590500802494538 – volume: 92 start-page: 481 year: 1981 end-page: 491 ident: CR34 article-title: Eustachian tube function in normal children and adults publication-title: Acta Otolaryngol. doi: 10.3109/00016488109133287 – volume: 13 start-page: 89 year: 2012 end-page: 94 ident: CR30 article-title: The occurrence of ultrafine particles in the specific environment of children publication-title: Paediatr. Respir. Rev. – volume: 115 start-page: 9592 year: 2018 end-page: 9597 ident: CR1 article-title: Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1803222115 – volume: 15 start-page: 257 year: 2018 ident: CR14 article-title: Air pollution and otitis media in children: A systematic review of literature publication-title: Int. J. Environ. Res. Public Health doi: 10.3390/ijerph15020257 – volume: 167 start-page: 144 year: 2018 end-page: 159 ident: CR6 article-title: Ambient air pollution and pregnancy outcomes: A comprehensive review and identification of environmental public health challenges publication-title: Environ. Res. doi: 10.1016/j.envres.2018.07.008 – ident: CR9 – volume: 15 start-page: 115 year: 2016 ident: CR37 article-title: Pediatric emergency department visits and ambient Air pollution in the U.S. State of Georgia: A case-crossover study publication-title: Environ. Health doi: 10.1186/s12940-016-0196-y – volume: 13 year: 2018 ident: CR13 article-title: Air pollution influences the incidence of otitis media in children: A national population-based study publication-title: PLoS One doi: 10.1371/journal.pone.0199296 – ident: CR26 – volume: 7 start-page: 47 year: 1986 end-page: 54 ident: CR43 article-title: Epidemiology of acute suppurative otitis media publication-title: Am. J. Otolaryngol. doi: 10.1016/S0196-0709(86)80034-5 – volume: 66 start-page: 395 year: 2011 end-page: 399 ident: CR41 article-title: Incidence and recurrence of acute otitis media in Taiwan's pediatric population publication-title: Clinics (Sao Paulo) doi: 10.1590/S1807-59322011000300005 – volume: 151 start-page: 333 year: 2014 end-page: 340 ident: CR12 article-title: Impact of otitis media severity on children's quality of life publication-title: Otolaryngol. Head Neck Surg. doi: 10.1177/0194599814525576 – volume: 48 start-page: 163 year: 2016 end-page: 171 ident: CR36 article-title: The air quality health index and emergency department visits for otitis media publication-title: J. Nurs. Scholarsh. doi: 10.1111/jnu.12195 – volume: 38 start-page: 395 year: 2014 end-page: 403 ident: CR20 article-title: Background and data configuration process of a nationwide population-based study using the Korean National Health Insurance System publication-title: Diabetes Metab. J. doi: 10.4093/dmj.2014.38.5.395 – volume: 58 start-page: 10 year: 2015 ident: CR52 article-title: The diagnosis and management of otitis media in children publication-title: J. Korean Med. Assoc. – ident: CR53 – volume: 50 start-page: 754 year: 2020 end-page: 772 ident: CR55 article-title: Cardiovascular Research Using the Korean National Health Information Database publication-title: Korean Circ. J. doi: 10.4070/kcj.2020.0171 – volume: 131 start-page: e964 year: 2013 end-page: e999 ident: CR21 article-title: The diagnosis and management of acute otitis media publication-title: Pediatrics doi: 10.1542/peds.2012-3488 – volume: 11 year: 2016 ident: CR29 article-title: Identification of potential novel biomarkers and signaling pathways related to otitis media induced by diesel exhaust particles using transcriptomic analysis in an in vivo system publication-title: PLoS One doi: 10.1371/journal.pone.0166044 – volume: 33 start-page: 269 year: 2006 end-page: 272 ident: CR32 article-title: Influence of air pollution on respiratory health during perinatal development publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1111/j.1440-1681.2006.04357.x – volume: 74 start-page: 136 year: 2015 end-page: 143 ident: CR5 article-title: A review on the human health impact of airborne particulate matter publication-title: Environ. Int. doi: 10.1016/j.envint.2014.10.005 – volume: 27 start-page: 110 year: 2015 end-page: 115 ident: CR16 article-title: Importance of viruses in acute otitis media publication-title: Curr. Opin. Pediatr. doi: 10.1097/MOP.0000000000000184 – volume: 118 start-page: 1631 year: 2010 end-page: 1636 ident: CR48 article-title: Air pollution and emergency department visits for otitis media: A case-crossover study in Edmonton, Canada publication-title: Environ. Health Perspect. doi: 10.1289/ehp.0901675 – ident: CR23 – volume: 78 start-page: 2193 year: 2014 end-page: 2197 ident: CR28 article-title: Middle ear inflammation of rat induced by urban particles publication-title: Int. J. Pediatr. Otorhinolaryngol. doi: 10.1016/j.ijporl.2014.10.011 – volume: 160 start-page: 83 year: 1989 end-page: 94 ident: CR40 article-title: Epidemiology of otitis media during the first seven years of life in children in greater Boston: A prospective, cohort study publication-title: J. Infect. Dis. doi: 10.1093/infdis/160.1.83 – volume: 22 start-page: 3 year: 2014 end-page: 11 ident: CR15 article-title: Differences between the spectra of respiratory illnesses in children living in urban and rural environments publication-title: Cent. Eur. J. Public Health doi: 10.21101/cejph.a3950 – volume: 27 start-page: 835 year: 2012 end-page: 848 ident: CR22 article-title: Korean clinical practice guidelines: Otitis media in children publication-title: J. Korean Med. Sci. doi: 10.3346/jkms.2012.27.8.835 – volume: 39 start-page: 19 year: 1983 end-page: 25 ident: CR44 article-title: Epidemiology of acute otitis media in children publication-title: Scand. J. Infect. Dis. Suppl. – volume: 178 start-page: 865 year: 2013 end-page: 876 ident: CR18 article-title: Evidence on vulnerability and susceptibility to health risks associated with short-term exposure to particulate matter: A systematic review and meta-analysis publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwt090 – volume: 145 year: 2020 ident: CR38 article-title: The impact of PM(2.5) on acute otitis media in children (aged 0–3): A time series study publication-title: Environ. Int. doi: 10.1016/j.envint.2020.106133 – volume: 114 start-page: 1414 year: 2006 end-page: 1418 ident: CR47 article-title: Traffic-related air pollution and otitis media publication-title: Environ. Health Perspect. doi: 10.1289/ehp.9089 – volume: 63 start-page: 685 year: 2017 end-page: 687 ident: CR51 article-title: Antibiotic therapy for children with acute otitis media publication-title: Can. Fam. Physician – volume: 16 start-page: 480 year: 2016 end-page: 492 ident: CR56 article-title: Prevention of early episodes of otitis media by pneumococcal vaccines might reduce progression to complex disease publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(15)00549-6 – volume: 344 start-page: 403 year: 2001 end-page: 409 ident: CR57 article-title: Efficacy of a pneumococcal conjugate vaccine against acute otitis media publication-title: N. Engl. J. Med. doi: 10.1056/NEJM200102083440602 – ident: CR24 – volume: 71 start-page: 238 year: 2008 end-page: 243 ident: CR31 article-title: Children's response to air pollutants publication-title: J. Toxicol. Environ. Health A doi: 10.1080/15287390701598234 – volume: 39 start-page: 663 year: 2017 ident: 99247_CR35 publication-title: Surg. Radiol. Anat. doi: 10.1007/s00276-016-1786-7 – volume: 78 start-page: 2193 year: 2014 ident: 99247_CR28 publication-title: Int. J. Pediatr. Otorhinolaryngol. doi: 10.1016/j.ijporl.2014.10.011 – volume: 145 year: 2020 ident: 99247_CR38 publication-title: Environ. Int. doi: 10.1016/j.envint.2020.106133 – volume: 151 start-page: 333 year: 2014 ident: 99247_CR12 publication-title: Otolaryngol. Head Neck Surg. doi: 10.1177/0194599814525576 – volume: 114 start-page: 1414 year: 2006 ident: 99247_CR47 publication-title: Environ. Health Perspect. doi: 10.1289/ehp.9089 – volume: 74 start-page: 136 year: 2015 ident: 99247_CR5 publication-title: Environ. Int. doi: 10.1016/j.envint.2014.10.005 – volume: 58 start-page: 10 year: 2015 ident: 99247_CR52 publication-title: J. Korean Med. Assoc. – volume: 71 start-page: 238 year: 2008 ident: 99247_CR31 publication-title: J. Toxicol. Environ. Health A doi: 10.1080/15287390701598234 – ident: 99247_CR26 – volume: 167 start-page: 144 year: 2018 ident: 99247_CR6 publication-title: Environ. Res. doi: 10.1016/j.envres.2018.07.008 – volume: 115 start-page: 9592 year: 2018 ident: 99247_CR1 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1803222115 – volume: 131 start-page: e964 year: 2013 ident: 99247_CR21 publication-title: Pediatrics doi: 10.1542/peds.2012-3488 – volume: 48 start-page: 163 year: 2016 ident: 99247_CR36 publication-title: J. Nurs. Scholarsh. doi: 10.1111/jnu.12195 – volume: 11 year: 2016 ident: 99247_CR29 publication-title: PLoS One doi: 10.1371/journal.pone.0166044 – volume: 9 start-page: 19421 year: 2019 ident: 99247_CR4 publication-title: Sci. Rep. doi: 10.1038/s41598-019-55956-4 – volume: 381 start-page: 705 year: 2019 ident: 99247_CR46 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1817364 – volume: 27 start-page: 110 year: 2015 ident: 99247_CR16 publication-title: Curr. Opin. Pediatr. doi: 10.1097/MOP.0000000000000184 – volume: 178 start-page: 865 year: 2013 ident: 99247_CR18 publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwt090 – volume: 22 start-page: 3 year: 2014 ident: 99247_CR15 publication-title: Cent. Eur. J. Public Health doi: 10.21101/cejph.a3950 – volume: 15 start-page: 115 year: 2016 ident: 99247_CR37 publication-title: Environ. Health doi: 10.1186/s12940-016-0196-y – ident: 99247_CR23 – volume: 8 start-page: 14 year: 2020 ident: 99247_CR3 publication-title: Front. Public Health doi: 10.3389/fpubh.2020.00014 – volume: 160 start-page: 83 year: 1989 ident: 99247_CR40 publication-title: J. Infect. Dis. doi: 10.1093/infdis/160.1.83 – volume: 13 year: 2018 ident: 99247_CR13 publication-title: PLoS One doi: 10.1371/journal.pone.0199296 – volume: 38 start-page: 395 year: 2014 ident: 99247_CR20 publication-title: Diabetes Metab. J. doi: 10.4093/dmj.2014.38.5.395 – volume: 119 start-page: 65 year: 1999 ident: 99247_CR45 publication-title: Acta Otolaryngol. doi: 10.1080/00016489950181963 – volume: 2021 year: 2021 ident: 99247_CR17 publication-title: Int. J. Pediatr. – volume: 92 start-page: 481 year: 1981 ident: 99247_CR34 publication-title: Acta Otolaryngol. doi: 10.3109/00016488109133287 – volume: 66 start-page: 395 year: 2011 ident: 99247_CR41 publication-title: Clinics (Sao Paulo) doi: 10.1590/S1807-59322011000300005 – volume: 63 start-page: 685 year: 2017 ident: 99247_CR51 publication-title: Can. Fam. Physician – volume: 50 start-page: 754 year: 2020 ident: 99247_CR55 publication-title: Korean Circ. J. doi: 10.4070/kcj.2020.0171 – ident: 99247_CR24 – volume: 3 start-page: 3S13 year: 1997 ident: 99247_CR39 publication-title: Clin. Microbiol. Infect. doi: 10.1016/S1198-743X(14)64947-8 – volume: 7 start-page: 47 year: 1986 ident: 99247_CR43 publication-title: Am. J. Otolaryngol. doi: 10.1016/S0196-0709(86)80034-5 – volume: 26 start-page: G2 issue: Suppl 7 year: 2008 ident: 99247_CR11 publication-title: Vaccine doi: 10.1016/j.vaccine.2008.11.005 – volume: 46 start-page: 179 year: 1998 ident: 99247_CR10 publication-title: Int. J. Pediatr. Otorhinolaryngol. doi: 10.1016/S0165-5876(98)00159-1 – volume: 20 start-page: 430 year: 2020 ident: 99247_CR2 publication-title: BMC Public Health doi: 10.1186/s12889-020-08503-0 – ident: 99247_CR19 – volume: 33 start-page: 269 year: 2006 ident: 99247_CR32 publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1111/j.1440-1681.2006.04357.x – volume: 27 start-page: 835 year: 2012 ident: 99247_CR22 publication-title: J. Korean Med. Sci. doi: 10.3346/jkms.2012.27.8.835 – volume: 28 start-page: 348 year: 2018 ident: 99247_CR49 publication-title: J. Expo Sci. Environ. Epidemiol. doi: 10.1038/s41370-017-0006-9 – volume: 76 start-page: 334 year: 2012 ident: 99247_CR27 publication-title: Int. J. Pediatr. Otorhinolaryngol. doi: 10.1016/j.ijporl.2011.12.003 – ident: 99247_CR25 – volume: 89 start-page: 20 year: 1980 ident: 99247_CR33 publication-title: Ann. Otol. Rhinol. Laryngol. Suppl. doi: 10.1177/00034894800890S308 – volume: 14 start-page: 809 year: 2010 ident: 99247_CR50 publication-title: Eur. Rev. Med. Pharmacol. Sci. – volume: 344 start-page: 403 year: 2001 ident: 99247_CR57 publication-title: N. Engl. J. Med. doi: 10.1056/NEJM200102083440602 – volume: 39 start-page: 19 year: 1983 ident: 99247_CR44 publication-title: Scand. J. Infect. Dis. Suppl. – volume: 118 start-page: 1631 year: 2010 ident: 99247_CR48 publication-title: Environ. Health Perspect. doi: 10.1289/ehp.0901675 – volume-title: Otitis Media in Infants and Children year: 2006 ident: 99247_CR42 – ident: 99247_CR53 – volume: 16 start-page: 480 year: 2016 ident: 99247_CR56 publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(15)00549-6 – ident: 99247_CR9 – volume: 174 start-page: 308 year: 2020 ident: 99247_CR54 publication-title: JAMA Pediatr. doi: 10.1001/jamapediatrics.2019.5664 – volume: 26 start-page: 339 year: 2008 ident: 99247_CR7 publication-title: J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. doi: 10.1080/10590500802494538 – volume: 15 start-page: 257 year: 2018 ident: 99247_CR14 publication-title: Int. J. Environ. Res. Public Health doi: 10.3390/ijerph15020257 – volume: 13 start-page: 89 year: 2012 ident: 99247_CR30 publication-title: Paediatr. Respir. Rev. – volume: 134 year: 2020 ident: 99247_CR8 publication-title: Int. J. Pediatr. Otorhinolaryngol. doi: 10.1016/j.ijporl.2020.110002
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Snippet	Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most common... Abstract Particulate matter (PM) is the main component of air pollution. Children are vulnerable to PM and acute otitis media (AOM), which is one of the most...
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SubjectTerms	692/308 692/499 692/699 704/172 704/844 Acute Disease Age Factors Age groups Air Pollutants Air Pollution Antibiotics Child Child, Preschool Children Disease Susceptibility Ear diseases Environmental Exposure Environmental research Exposure Female Humanities and Social Sciences Humans Incidence Infant Infant, Newborn Male multidisciplinary Otitis media Otitis Media - epidemiology Otitis Media - etiology Particle Size Particulate matter Particulate Matter - adverse effects Public Health Surveillance Republic of Korea - epidemiology Risk Factors Science Science (multidisciplinary) Seasons
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Title	Particular matter influences the incidence of acute otitis media in children
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