A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer

The independent effects of smoking and alcohol in head and neck cancer are not clear, given the strong association between these risk factors. Their apparent synergistic effect reported in previous observational studies may also underestimate independent effects. Here we report multivariable Mendeli...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 6071 - 10
Main Authors:	Gormley, Mark, Dudding, Tom, Sanderson, Eleanor, Martin, Richard M., Thomas, Steven, Tyrrell, Jessica, Ness, Andrew R., Brennan, Paul, Munafò, Marcus, Pring, Miranda, Boccia, Stefania, Olshan, Andrew F., Diergaarde, Brenda, Hung, Rayjean J., Liu, Geoffrey, Davey Smith, George, Richmond, Rebecca C.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.11.2020 Nature Publishing Group Nature Portfolio
Subjects:	45 45/43 631/114 631/67/1536 631/67/1665 631/67/2195 Alcohol Alcohol Drinking - genetics Alcohol use Alcoholic beverages Alcohols Cancer Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Head & neck cancer Health risks Humanities and Social Sciences Humans Mendelian Randomization Analysis Mouth Neoplasms - genetics multidisciplinary Multivariate Analysis Observational studies Oral cancer Oropharyngeal cancer Oropharyngeal Neoplasms - genetics Polymorphism, Single Nucleotide - genetics Randomization Risk analysis Risk Factors Science Science (multidisciplinary) Sexual Partners Smoking Smoking - genetics Standard deviation Synergistic effect Throat cancer
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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