Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS

Although the importance of reactive astrocytes during CNS pathology is well established, the function of astroglia in adult CNS homeostasis is less well understood. With the use of conditional, astrocyte-restricted protein synthesis termination, we found that selective paralysis of GFAP+ astrocytes...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 12; H. 9; S. 1377 - 1384
Hauptverfasser:	Schreiner, Bettina, Romanelli, Elisa, Liberski, Pawel, Ingold-Heppner, Barbara, Sobottka-Brillout, Bettina, Hartwig, Tom, Chandrasekar, Vijay, Johannssen, Helge, Zeilhofer, Hanns Ulrich, Aguzzi, Adriano, Heppner, Frank, Kerschensteiner, Martin, Becher, Burkhard
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.09.2015 Elsevier
Schlagworte:	Animals Antioxidants - pharmacology Astrocytes - metabolism Brain - cytology Brain - drug effects Brain - growth & development Brain - metabolism Cell Death Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Mice Motor Neurons - metabolism Oxidative Stress Reactive Nitrogen Species - metabolism Reactive Oxygen Species - metabolism
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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