A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2

Respiratory tract vaccination has an advantage of needle-free delivery and induction of mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human parainfluenza virus type 3 vector to generate constructs expressing the full spike (S) protein of SARS-CoV-2, its S1 subunit, or the re...

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Veröffentlicht in:	npj vaccines Jg. 7; H. 1; S. 47 - 16
Hauptverfasser:	Ilinykh, Philipp A., Periasamy, Sivakumar, Huang, Kai, Kuzmina, Natalia A., Ramanathan, Palaniappan, Meyer, Michelle N., Mire, Chad E., Kuzmin, Ivan V., Bharaj, Preeti, Endsley, Jessica R., Chikina, Maria, Sealfon, Stuart C., Widen, Steven G., Endsley, Mark A., Bukreyev, Alexander
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 25.04.2022 Nature Publishing Group Nature Portfolio
Schlagworte:	631/250/255/2514 631/250/590/1867 631/326/596/4130 692/420/256/2516 Antibodies Biomedical and Life Sciences Biomedicine COVID-19 COVID-19 vaccines Immune response Infectious Diseases Influenza Medical Microbiology Protected animals Proteins Public Health Respiratory tract Rodents Severe acute respiratory syndrome coronavirus 2 Vaccine Vaccines Virology
ISSN:	2059-0105, 2059-0105
Online-Zugang:	Volltext
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