RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse

Protein kinases (PKs) are a class of druggable targets in Trypanosoma brucei , the causative agent of Human African Trypanosomiasis (sleeping sickness), yet little is known about which PKs are essential for survival in mammals. A recent kinome-wide RNAi screen with 176 individual bloodstream form Tr...

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Veröffentlicht in:	Scientific reports Jg. 7; H. 1; S. 6156 - 10
Hauptverfasser:	Fernandez-Cortes, Fernando, Serafim, Tiago D., Wilkes, Jonathan M., Jones, Nathaniel G., Ritchie, Ryan, McCulloch, Richard, Mottram, Jeremy C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 21.07.2017 Nature Publishing Group Nature Portfolio
Schlagworte:	1-Phosphatidylinositol 3-kinase 13 13/89 13/95 45/23 631/326/417/1716 631/326/417/2551 64/60 African trypanosomiasis Complement system Fitness Humanities and Social Sciences Kinases Lysis MAP kinase multidisciplinary Parasites Protein kinase Proteins Protozoa RNA-mediated interference Science Science (multidisciplinary) Survival Trypanosoma brucei Vector-borne diseases Virulence factors
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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