A cryptic pocket in Ebola VP35 allosterically controls RNA binding

Protein-protein and protein-nucleic acid interactions are often considered difficult drug targets because the surfaces involved lack obvious druggable pockets. Cryptic pockets could present opportunities for targeting these interactions, but identifying and exploiting these pockets remains challengi...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 2269 - 10
Main Authors:	Cruz, Matthew A., Frederick, Thomas E., Mallimadugula, Upasana L., Singh, Sukrit, Vithani, Neha, Zimmerman, Maxwell I., Porter, Justin R., Moeder, Katelyn E., Amarasinghe, Gaya K., Bowman, Gregory R.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.04.2022 Nature Publishing Group Nature Portfolio
Subjects:	119/118 38/71 45/70 631/45/612/1230 631/45/612/1256 631/57/2266 82/80 82/83 96/34 Adaptive sampling Algorithms Allosteric properties Binding sites Computer applications DNA Viruses - genetics Double-stranded RNA Drug development Ebola virus Ebolavirus Ebolavirus - genetics Hemorrhagic Fever, Ebola Humanities and Social Sciences Humans Interferon Machine learning multidisciplinary Nucleic acids Proteins RNA, Double-Stranded - genetics RNA-binding protein Science Science (multidisciplinary) Therapeutic targets Viral diseases Viral Proteins - genetics Viral Regulatory and Accessory Proteins - genetics
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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