Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming

Insufficient eradication capacity and dysfunction are common occurrences in T cells that characterize cancer immunotherapy failure. De novo DNA methylation promotes T cell exhaustion, whereas methylation inhibition enhances T cell rejuvenation in vivo. Decitabine, a DNA methyltransferase inhibitor a...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 409 - 18
Main Authors:	Wang, Yao, Tong, Chuan, Dai, Hanren, Wu, Zhiqiang, Han, Xiao, Guo, Yelei, Chen, Deyun, Wei, Jianshu, Ti, Dongdong, Liu, Zongzhi, Mei, Qian, Li, Xiang, Dong, Liang, Nie, Jing, Zhang, Yajing, Han, Weidong
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.01.2021 Nature Publishing Group Nature Portfolio
Subjects:	101/1 13/1 13/2 13/21 13/31 13/51 14/32 38/23 38/91 5-aza-2'-deoxycytidine 631/67/1059/2325 64/60 692/308/575 Animals Anticancer properties Antigens Cancer Cancer immunotherapy CD19 antigen Cell Culture Techniques - methods Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Proliferation - genetics Chimeric antigen receptors Cytokines Cytokines - genetics Cytokines - immunology Decitabine - pharmacology Deoxyribonucleic acid DNA DNA methylation DNA Methylation - drug effects DNA methyltransferase Dose-Response Relationship, Drug Epigenesis, Genetic - drug effects Epigenesis, Genetic - immunology Epigenetics Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - immunology Genes Humanities and Social Sciences Humans Immunological memory Immunotherapy Immunotherapy, Adoptive - methods Inhibitors Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Memory cells Mice multidisciplinary Neoplasms - blood Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy Pretreatment Priming Receptors, Chimeric Antigen - immunology RNA-Seq Science Science (multidisciplinary) T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - transplantation Tumors Xenograft Model Antitumor Assays
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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