A BDNF-TrkB autocrine loop enhances senescent cell viability

Cellular senescence is characterized by cell cycle arrest, resistance to apoptosis, and a senescence-associated secretory phenotype (SASP) whereby cells secrete pro-inflammatory and tissue-remodeling factors. Given that the SASP exacerbates age-associated pathologies, some aging interventions aim at...

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Veröffentlicht in:	Nature communications Jg. 13; H. 1; S. 6228 - 17
Hauptverfasser:	Anerillas, Carlos, Herman, Allison B., Munk, Rachel, Garrido, Amanda, Lam, Kwan-Wood Gabriel, Payea, Matthew J., Rossi, Martina, Tsitsipatis, Dimitrios, Martindale, Jennifer L., Piao, Yulan, Mazan-Mamczarz, Krystyna, Fan, Jinshui, Cui, Chang-Yi, De, Supriyo, Abdelmohsen, Kotb, de Cabo, Rafael, Gorospe, Myriam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 20.10.2022 Nature Publishing Group Nature Portfolio
Schlagworte:	13/106 38/89 631/337/1427/2566 631/443/7 631/80/509 Ablation Accumulation Aging Animals Apoptosis Autocrine signalling Brain-Derived Neurotrophic Factor Cell cycle Cell Survival Cell viability Cellular Senescence - genetics Humanities and Social Sciences Humans Inflammation Ligands Mice multidisciplinary Organs Phenotypes Science Science (multidisciplinary) Senescence Survival TrkB receptors
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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