The effect of X-linked dosage compensation on complex trait variation

Quantitative genetics theory predicts that X-chromosome dosage compensation (DC) will have a detectable effect on the amount of genetic and therefore phenotypic trait variances at associated loci in males and females. Here, we systematically examine the role of DC in humans in 20 complex traits in a...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 3009 - 11
Main Authors:	Sidorenko, Julia, Kassam, Irfahan, Kemper, Kathryn E., Zeng, Jian, Lloyd-Jones, Luke R., Montgomery, Grant W., Gibson, Greg, Metspalu, Andres, Esko, Tonu, Yang, Jian, McRae, Allan F., Visscher, Peter M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.07.2019 Nature Publishing Group Nature Portfolio
Subjects:	631/208/176/1433 631/208/199 631/208/212 631/208/729 Chromosomes Compensation Datasets as Topic Deactivation Dosage Dosage compensation Female Females Gene expression Genes, X-Linked - genetics Genetic diversity Genetic Loci - genetics Genetic Variation - genetics Genetics Genome-Wide Association Study Heterogeneity Humanities and Social Sciences Humans Inactivation Male Males Models, Genetic multidisciplinary Multifactorial Inheritance - genetics Phenotype Quantitative genetics Science Science (multidisciplinary) Sex Factors X Chromosome Inactivation - genetics X chromosomes United Kingdom > UK
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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