MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

The limited efficacy of immune checkpoint inhibitor treatment in triple-negative breast cancer (TNBC) patients is attributed to sparse or unresponsive tumor-infiltrating lymphocytes, but the mechanisms that lead to a therapy resistant tumor immune microenvironment are incompletely known. Here we sho...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 6579 - 18
Main Authors:	Zimmerli, Dario, Brambillasca, Chiara S., Talens, Francien, Bhin, Jinhyuk, Linstra, Renske, Romanens, Lou, Bhattacharya, Arkajyoti, Joosten, Stacey E. P., Da Silva, Ana Moises, Padrao, Nuno, Wellenstein, Max D., Kersten, Kelly, de Boo, Mart, Roorda, Maurits, Henneman, Linda, de Bruijn, Roebi, Annunziato, Stefano, van der Burg, Eline, Drenth, Anne Paulien, Lutz, Catrin, Endres, Theresa, van de Ven, Marieke, Eilers, Martin, Wessels, Lodewyk, de Visser, Karin E., Zwart, Wilbert, Fehrmann, Rudolf S. N., van Vugt, Marcel A. T. M., Jonkers, Jos
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02.11.2022 Nature Publishing Group Nature Portfolio
Subjects:	13/106 13/51 38/109 45/91 49/15 49/31 49/39 631/250/127/1212 631/250/580 631/67/1347 631/67/327 64 64/60 96 Animal models Animals BRCA1 protein Breast cancer Cell activation Cell culture Cell Line, Tumor Chromatin Genes Growth inhibition Humanities and Social Sciences Humans Immune checkpoint inhibitors Immunity Immunogenicity Immunoprecipitation Inactivation Inflammation Innate immunity Interferon Interferons Lymphocytes Lymphocytes, Tumor-Infiltrating Metastases Mice Microenvironments multidisciplinary Myc protein Proto-Oncogene Proteins c-myc - metabolism Science Science (multidisciplinary) Signal Transduction Signaling Stimulators Triple Negative Breast Neoplasms - metabolism Tumor microenvironment Tumor Microenvironment - genetics Tumor-infiltrating lymphocytes Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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