MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

The limited efficacy of immune checkpoint inhibitor treatment in triple-negative breast cancer (TNBC) patients is attributed to sparse or unresponsive tumor-infiltrating lymphocytes, but the mechanisms that lead to a therapy resistant tumor immune microenvironment are incompletely known. Here we sho...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature communications Ročník 13; číslo 1; s. 6579 - 18
Hlavní autoři:	Zimmerli, Dario, Brambillasca, Chiara S., Talens, Francien, Bhin, Jinhyuk, Linstra, Renske, Romanens, Lou, Bhattacharya, Arkajyoti, Joosten, Stacey E. P., Da Silva, Ana Moises, Padrao, Nuno, Wellenstein, Max D., Kersten, Kelly, de Boo, Mart, Roorda, Maurits, Henneman, Linda, de Bruijn, Roebi, Annunziato, Stefano, van der Burg, Eline, Drenth, Anne Paulien, Lutz, Catrin, Endres, Theresa, van de Ven, Marieke, Eilers, Martin, Wessels, Lodewyk, de Visser, Karin E., Zwart, Wilbert, Fehrmann, Rudolf S. N., van Vugt, Marcel A. T. M., Jonkers, Jos
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 02.11.2022 Nature Publishing Group Nature Portfolio
Témata:	13/106 13/51 38/109 45/91 49/15 49/31 49/39 631/250/127/1212 631/250/580 631/67/1347 631/67/327 64 64/60 96 Animal models Animals BRCA1 protein Breast cancer Cell activation Cell culture Cell Line, Tumor Chromatin Genes Growth inhibition Humanities and Social Sciences Humans Immune checkpoint inhibitors Immunity Immunogenicity Immunoprecipitation Inactivation Inflammation Innate immunity Interferon Interferons Lymphocytes Lymphocytes, Tumor-Infiltrating Metastases Mice Microenvironments multidisciplinary Myc protein Proto-Oncogene Proteins c-myc - metabolism Science Science (multidisciplinary) Signal Transduction Signaling Stimulators Triple Negative Breast Neoplasms - metabolism Tumor microenvironment Tumor Microenvironment - genetics Tumor-infiltrating lymphocytes Tumors
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!