Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

Few studies have explored the impact of rare variants (minor allele frequency < 1%) on highly heritable plasma metabolites identified in metabolomic screens. The Finnish population provides an ideal opportunity for such explorations, given the multiple bottlenecks and expansions that have shaped...

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Vydáno v:	Nature communications Ročník 13; číslo 1; s. 1644 - 14
Hlavní autoři:	Yin, Xianyong, Chan, Lap Sum, Bose, Debraj, Jackson, Anne U., VandeHaar, Peter, Locke, Adam E., Fuchsberger, Christian, Stringham, Heather M., Welch, Ryan, Yu, Ketian, Fernandes Silva, Lilian, Service, Susan K., Zhang, Daiwei, Hector, Emily C., Young, Erica, Ganel, Liron, Das, Indraniel, Abel, Haley, Erdos, Michael R., Bonnycastle, Lori L., Kuusisto, Johanna, Stitziel, Nathan O., Hall, Ira M., Wagner, Gregory R., Kang, Jian, Morrison, Jean, Burant, Charles F., Collins, Francis S., Ripatti, Samuli, Palotie, Aarno, Freimer, Nelson B., Mohlke, Karen L., Scott, Laura J., Wen, Xiaoquan, Fauman, Eric B., Laakso, Markku, Boehnke, Michael
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 28.03.2022 Nature Publishing Group Nature Portfolio
Témata:	45/43 631/208/205/2138 631/208/729/743 692/53 Alleles Disease Enrichment Finland Gene Frequency Genetic diversity Genetic Predisposition to Disease Genetic variance Genome-wide association studies Genome-Wide Association Study - methods Genomes Humanities and Social Sciences Humans Loci Male Metabolites Metabolomics multidisciplinary Phenotype Polymorphism, Single Nucleotide Population genetics Science Science (multidisciplinary) Finland
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
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