Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia

AMPK is a master regulator of cellular metabolism that exerts either oncogenic or tumor suppressor activity depending on context. Here, we report that the specific AMPK agonist GSK621 selectively kills acute myeloid leukemia (AML) cells but spares normal hematopoietic progenitors. This differential...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 11; H. 9; S. 1446 - 1457
Hauptverfasser:	Sujobert, Pierre, Poulain, Laury, Paubelle, Etienne, Zylbersztejn, Florence, Grenier, Adrien, Lambert, Mireille, Townsend, Elizabeth C., Brusq, Jean-Marie, Nicodeme, Edwige, Decrooqc, Justine, Nepstad, Ina, Green, Alexa S., Mondesir, Johanna, Hospital, Marie-Anne, Jacque, Nathalie, Christodoulou, Alexandra, Desouza, Tiffany A., Hermine, Olivier, Foretz, Marc, Viollet, Benoit, Lacombe, Catherine, Mayeux, Patrick, Weinstock, David M., Moura, Ivan C., Bouscary, Didier, Tamburini, Jerome
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 09.06.2015 Elsevier
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Antineoplastic Agents - pharmacology Enzyme Activation - drug effects Fluorescent Antibody Technique Heterografts Humans Imidazoles - pharmacology Leukemia, Myeloid, Acute - metabolism Mechanistic Target of Rapamycin Complex 1 Mice Mice, Nude Microscopy, Electron, Transmission Multiprotein Complexes - agonists Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Pyrimidinones - pharmacology RNA Interference Signal Transduction - drug effects TOR Serine-Threonine Kinases
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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