Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been associated with DCM, but common variant studies of the disease have yielded few associated loci. As structural changes in the heart are a def...

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Vydáno v:	Nature communications Ročník 11; číslo 1; s. 2254 - 10
Hlavní autoři:	Pirruccello, James P., Bick, Alexander, Wang, Minxian, Chaffin, Mark, Friedman, Samuel, Yao, Jie, Guo, Xiuqing, Venkatesh, Bharath Ambale, Taylor, Kent D., Post, Wendy S., Rich, Stephen, Lima, Joao A. C., Rotter, Jerome I., Philippakis, Anthony, Lubitz, Steven A., Ellinor, Patrick T., Khera, Amit V., Kathiresan, Sekar, Aragam, Krishna G.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 07.05.2020 Nature Publishing Group Nature Portfolio
Témata:	45/43 59/57 631/208/205/2138 631/443/592/2727 692/4019/592/75/74 Arteriosclerosis Atherosclerosis Cardiomyopathy Cardiomyopathy, Dilated - diagnostic imaging Cardiomyopathy, Dilated - genetics Congestive heart failure Dilated cardiomyopathy Genetic diversity Genetic variance Genome-wide association studies Genome-Wide Association Study Genomes Heart Heart - diagnostic imaging Heart transplantation Humanities and Social Sciences Humans Loci Magnetic Resonance Imaging Medical imaging multidisciplinary Mutation Myocardium - metabolism Pathogenesis Polymorphism, Single Nucleotide - genetics Science Science (multidisciplinary) Structure-function relationships Transplantation Ventricle
ISSN:	2041-1723, 2041-1723
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