Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model

Although preoperative chemoradiation therapy can down-stage locally advanced rectal cancer (LARC), it has little effect on distant metastases. Metformin exerts an anti-cancer effect partly through the activation of host immunity. LuM1, a highly lung metastatic subclone of colon 26, was injected subc...

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Veröffentlicht in:	Scientific reports Jg. 12; H. 1; S. 7290 - 12
Hauptverfasser:	Tojo, Mineyuki, Miyato, Hideyo, Koinuma, Koji, Horie, Hisanaga, Tsukui, Hidenori, Kimura, Yuki, Kaneko, Yuki, Ohzawa, Hideyuki, Yamaguchi, Hironori, Yoshimura, Kotaro, Lefor, Alan Kawarai, Sata, Naohiro, Kitayama, Joji
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 04.05.2022 Nature Publishing Group Nature Portfolio
Schlagworte:	631/250 631/67 692/4020 692/4028 Animals Antidiabetics Cancer Cancer therapies CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes Cell activation Cell-mediated immunity Chemoradiotherapy Colorectal cancer Combined treatment Flow cytometry Humanities and Social Sciences Immunohistochemistry Irradiation Lung cancer Lung Neoplasms - pathology Lungs Lymphocytes T Metastases Metastasis Metformin Metformin - pharmacology Mice Mice, Inbred BALB C multidisciplinary Phenotypes Radiation Rectal Neoplasms - drug therapy Rectal Neoplasms - radiotherapy Rectum Science Science (multidisciplinary) Spleen Tumors γ-Interferon
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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