miR-146a modulates TLR1/2 and 4 induced inflammation and links it with proliferation and lipid production via the indirect regulation of GNG7 in human SZ95 sebocytes

Activation of Toll-like receptors (TLR) 1/2 and 4 are central in inducing inflammation in sebocytes by regulating the expression of protein coding mRNAs, however the microRNA (miRNA) profile in response to TLR activation and thus the possible role of miRNAs in modulating sebocyte functions has not b...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; pp. 21510 - 13
Main Authors:	Dull, Katalin, Fazekas, Fruzsina, Deák, Dávid, Kovács, Dóra, Póliska, Szilárd, Szegedi, Andrea, Zouboulis, Christos C., Törőcsik, Dániel
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02.11.2021 Nature Publishing Group Nature Portfolio
Subjects:	631/80 692/308 Acne Acne Vulgaris - genetics Acne Vulgaris - immunology Acne Vulgaris - metabolism Acne Vulgaris - pathology Adult Case-Control Studies Cell Proliferation Cells, Cultured Down-regulation Gene expression Gene Expression Regulation GTP-Binding Protein gamma Subunits - genetics GTP-Binding Protein gamma Subunits - metabolism Humanities and Social Sciences Humans Hybridization Inflammation Inflammation - genetics Inflammation - immunology Inflammation - metabolism Inflammation - pathology Interleukin 8 Lipids Lipids - analysis Lipogenesis Male MicroRNAs MicroRNAs - genetics miRNA multidisciplinary RNA-Seq Science Science (multidisciplinary) Sebaceous gland Sebaceous Glands - immunology Sebaceous Glands - metabolism Sebaceous Glands - pathology TLR1 protein Toll-Like Receptor 1 - genetics Toll-Like Receptor 1 - metabolism Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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