Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour

Recent analyses have shown educational attainment to be associated with a number of health outcomes. This association may, in part, be due to an effect of educational attainment on smoking behaviour. In this study, we apply a multivariable Mendelian randomisation design to determine whether the effe...

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Vydáno v:Nature communications Ročník 10; číslo 1; s. 2949 - 9
Hlavní autoři: Sanderson, Eleanor, Davey Smith, George, Bowden, Jack, Munafò, Marcus R.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 03.07.2019
Nature Publishing Group
Nature Portfolio
Témata:
631/208/205/2138
692/308/174
706/689/160
706/689/477/2811
Bias
Cognition - physiology
Cognitive ability
Education
Educational attainment
Educational Status
Genome-Wide Association Study
Health risk assessment
Humanities and Social Sciences
Humans
Mendelian Randomization Analysis
multidisciplinary
Odds Ratio
Randomization
Science
Science (multidisciplinary)
Smoking
Smoking - genetics
ISSN:2041-1723, 2041-1723
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Popis
Shrnutí:Recent analyses have shown educational attainment to be associated with a number of health outcomes. This association may, in part, be due to an effect of educational attainment on smoking behaviour. In this study, we apply a multivariable Mendelian randomisation design to determine whether the effect of educational attainment on smoking behaviour is due to educational attainment or general cognitive ability. We use individual data from the UK Biobank study ( N  = 120,050) and summary data from large GWA studies of educational attainment, cognitive ability and smoking behaviour. Our results show that more years of education are associated with a reduced likelihood of smoking that is not due to an effect of general cognitive ability on smoking behaviour. Given the considerable physical harms associated with smoking, the effect of educational attainment on smoking is likely to contribute to the health inequalities associated with differences in educational attainment. Higher educational attainment is positively associated with a number of health outcomes. Here, Sanderson et al. use multivariable Mendelian randomisation analysis to test whether the association of educational attainment with smoking behaviour is direct or indirectly mediated via general cognitive ability.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-019-10679-y