Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

Abstarct Glaucoma is a chronic disease that shares many similarities with other neurodegenerative disorders of the central nervous system. This study was designed to evaluate the association between glaucoma and other neurodegenerative disorders by investigating glaucoma-associated protein changes i...

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Bibliographic Details
Published in:	Scientific reports Vol. 7; no. 1; pp. 12685 - 16
Main Authors:	Mirzaei, Mehdi, Gupta, Veer B., Chick, Joel M., Greco, Todd M., Wu, Yunqi, Chitranshi, Nitin, Wall, Roshana Vander, Hone, Eugene, Deng, Liting, Dheer, Yogita, Abbasi, Mojdeh, Rezaeian, Mahdie, Braidy, Nady, You, Yuyi, Salekdeh, Ghasem Hosseini, Haynes, Paul A., Molloy, Mark P., Martins, Ralph, Cristea, Ileana M., Gygi, Steven P., Graham, Stuart L., Gupta, Vivek K.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.10.2017 Nature Publishing Group
Subjects:	631/1647/2067 631/553 82/58 82/80 Aged Aging - metabolism Aging - pathology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Biomarkers - metabolism Blood Coagulation Central nervous system Cholesterol - metabolism Complement Activation Complement System Proteins - metabolism Disease Down-Regulation Electron Transport Eye Proteins - metabolism Female Glaucoma Glaucoma - metabolism Humanities and Social Sciences Humans Inflammation Male Membrane Transport Proteins - metabolism Middle Aged Mitochondria Mitochondria - metabolism multidisciplinary Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Oxidative phosphorylation Pathogenesis Phosphorylation Protein Interaction Maps Proteins Proteome - metabolism Proteomics Quality Control Retina Retina - metabolism Science Science (multidisciplinary) Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry Up-Regulation Vitreous Body - metabolism
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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