The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues

The small G protein family Rac has numerous regulators that integrate extracellular signals into tight spatiotemporal maps of its activity to promote specific cell morphologies and responses. Here, we have generated a mouse strain, Rac-FRET, which ubiquitously expresses the Raichu-Rac biosensor. It...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 6; H. 6; S. 1153 - 1164
Hauptverfasser:	Johnsson, Anna-Karin E., Dai, Yanfeng, Nobis, Max, Baker, Martin J., McGhee, Ewan J., Walker, Simon, Schwarz, Juliane P., Kadir, Shereen, Morton, Jennifer P., Myant, Kevin B., Huels, David J., Segonds-Pichon, Anne, Sansom, Owen J., Anderson, Kurt I., Timpson, Paul, Welch, Heidi C.E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Cell Press 01.03.2014 Elsevier
Schlagworte:	Animals Enzyme Activation Fluorescence Resonance Energy Transfer - methods Mice Neutrophils - cytology Neutrophils - enzymology rac GTP-Binding Proteins - chemistry rac GTP-Binding Proteins - metabolism Resource Signal Transduction Spatio-Temporal Analysis
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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