Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays key roles in many biol...

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Bibliographic Details
Published in:Signal transduction and targeted therapy Vol. 6; no. 1; pp. 400 - 17
Main Authors: Xue, Chen, Li, Ganglei, Lu, Juan, Li, Lanjuan
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 24.11.2021
Nature Publishing Group
Subjects:
1-Phosphatidylinositol 3-kinase
631/67/1059
631/67/395
AKT protein
Angiogenesis
Cancer
Cancer Research
Cell Biology
Cell migration
Cell proliferation
Gene expression
Humans
Internal Medicine
Kinases
Medicine
Medicine & Public Health
Neoplasms - genetics
Neoplasms - metabolism
Oncology
Pathology
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
Proto-Oncogene Proteins c-akt - genetics
Proto-Oncogene Proteins c-akt - metabolism
Review
Review Article
RNA, Circular - genetics
RNA, Circular - metabolism
RNA, Neoplasm - genetics
RNA, Neoplasm - metabolism
Signal Transduction
Transcription
Tumors
ISSN:2059-3635, 2095-9907, 2059-3635
Online Access:Get full text
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Summary:Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays key roles in many biological and cellular processes, such as cell proliferation, growth, invasion, migration, and angiogenesis. It also plays a pivotal role in cancer progression. Emerging data suggest that the circRNA/PI3K/AKT axis modulates the expression of cancer-associated genes and thus regulates tumor progression. Aberrant regulation of the expression of circRNAs in the circRNA/PI3K/AKT axis is significantly associated with clinicopathological characteristics and plays an important role in the regulation of biological functions. In this review, we summarized the expression and biological functions of PI3K-AKT-related circRNAs in vitro and in vivo and assessed their associations with clinicopathological characteristics. We also further discussed the important role of circRNAs in the diagnosis, prognostication, and treatment of cancers.
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ISSN:2059-3635
2095-9907
2059-3635
DOI:10.1038/s41392-021-00788-w