Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

Collagen-producing cells maintain the complex architecture of the lung and drive pathologic scarring in pulmonary fibrosis. Here we perform single-cell RNA-sequencing to identify all collagen-producing cells in normal and fibrotic lungs. We characterize multiple collagen-producing subpopulations wit...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 1920 - 16
Main Authors:	Tsukui, Tatsuya, Sun, Kai-Hui, Wetter, Joseph B., Wilson-Kanamori, John R., Hazelwood, Lisa A., Henderson, Neil C., Adams, Taylor S., Schupp, Jonas C., Poli, Sergio D., Rosas, Ivan O., Kaminski, Naftali, Matthay, Michael A., Wolters, Paul J., Sheppard, Dean
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 21.04.2020 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/31 13/51 14/19 14/35 38/32 38/39 38/88 38/90 38/91 631/1647/514/2254 64/110 64/60 692/699/1785 Adoptive transfer Animals Architecture Cell Separation Collagen Collagen - chemistry Extracellular Matrix Proteins - metabolism Female Fibroblasts Fibroblasts - metabolism Fibrosis Flow Cytometry Gene sequencing Green Fluorescent Proteins - metabolism Heterogeneity High-Throughput Nucleotide Sequencing Homeostasis Humanities and Social Sciences Humans Hybridization Idiopathic Pulmonary Fibrosis - pathology Localization Lung - metabolism Lung - pathology Lung diseases Lungs Male Mice Mice, Inbred C57BL multidisciplinary Phenotype Phenotypes Pulmonary fibrosis Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Respiration Disorders - metabolism Ribonucleic acid RNA Scars Science Science (multidisciplinary) Scleroderma Single-Cell Analysis Subpopulations
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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