Dopaminergic Control of Striatal Cholinergic Interneurons Underlies Cocaine-Induced Psychostimulation

Cocaine drastically elevates dopamine (DA) levels in the striatum, a brain region that is critical to the psychomotor and rewarding properties of the drug. DA signaling regulates intrastriatal circuits connecting medium spiny neurons (MSNs) with afferent fibers and interneurons. While the cocaine-me...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 31; no. 3; p. 107527
Main Authors:	Lewis, Robert G., Serra, Marcello, Radl, Daniela, Gori, Michela, Tran, Catherine, Michalak, Sharon E., Vanderwal, Christopher D., Borrelli, Emiliana
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 21.04.2020 Elsevier
Subjects:	acetylcholine Acetylcholine - metabolism addiction Animals ChI-D2RKO mice Cholinergic Neurons - drug effects Cholinergic Neurons - metabolism cholingeric interneuron cocaine Cocaine - pharmacology Corpus Striatum - drug effects Corpus Striatum - metabolism dopamine Dopamine - metabolism dopamine D2 receptor Female Interneurons - drug effects Interneurons - metabolism medium spiny neurons Mice Mice, Knockout Muscarinic Antagonists - pharmacology Receptors, Dopamine D2 - deficiency Receptors, Dopamine D2 - metabolism Receptors, Muscarinic - metabolism reward Signal Transduction - drug effects striatum Transcriptome - drug effects reward cholingeric interneuron striatum dopamine D2 receptor cocaine ChI-D2RKO mice addiction medium spiny neurons acetylcholine dopamine
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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