Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling

ADGRL4/ELTD1 is an orphan adhesion GPCR (aGPCR) expressed in endothelial cells that regulates tumour angiogenesis. The majority of aGPCRs are orphan receptors. The Stachel Hypothesis proposes a mechanism for aGPCR activation, in which aGPCRs contain a tethered agonist (termed Stachel ) C-terminal to...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; pp. 8870 - 13
Main Authors:	Favara, David M., Liebscher, Ines, Jazayeri, Ali, Nambiar, Madhulika, Sheldon, Helen, Banham, Alison H., Harris, Adrian L.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.04.2021 Nature Publishing Group Nature Portfolio
Subjects:	1-Phosphatidylinositol 3-kinase 631/80 631/80/86 Adhesion AKT protein Angiogenesis Codon Endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fluorescence resonance energy transfer G protein-coupled receptors HEK293 Cells Human Umbilical Vein Endothelial Cells Humanities and Social Sciences Humans Hypotheses Hypoxia-inducible factor 1a MAP kinase multidisciplinary Neovascularization, Pathologic Orphan receptors Peptides Phenotypes Proteolysis Receptors, G-Protein-Coupled - metabolism Science Science (multidisciplinary) Signal Transduction Stat3 protein Transcription Tumors Up-Regulation β-Catenin
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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