Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs

Most cells constitutively secrete mitochondrial DNA and proteins in extracellular vesicles (EVs). While EVs are small vesicles that transfer material between cells, Mitochondria-Derived Vesicles (MDVs) carry material specifically between mitochondria and other organelles. Mitochondrial content can e...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 1971 - 12
Main Authors:	Todkar, Kiran, Chikhi, Lilia, Desjardins, Véronique, El-Mortada, Firas, Pépin, Geneviève, Germain, Marc
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.03.2021 Nature Publishing Group Nature Portfolio
Subjects:	13 13/106 14 14/19 38 38/77 631/250/256 631/80/313 631/80/642/333 82/1 82/29 96 Alarmins - metabolism Atrophy Damage patterns DNA, Mitochondrial - metabolism Extracellular vesicles Extracellular Vesicles - metabolism GTP Phosphohydrolases - metabolism Humanities and Social Sciences Humans Immune response Inflammation Inflammation - metabolism Lysosomes Lysosomes - metabolism Mitochondria Mitochondria - metabolism Mitochondrial DNA Mitochondrial Proteins - metabolism Movement disorders multidisciplinary Neurodegenerative diseases Nexin Optic atrophy Organelles Packaging Parkin protein Parkinson Disease - metabolism Parkinson's disease Proteins Quality control Science Science (multidisciplinary) Sorting Nexins - metabolism Ubiquitin-Protein Ligases - metabolism Vesicles
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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