CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer

Cancer-associated fibroblasts (CAFs) are abundantly present in the microenvironment of virtually all tumors and strongly impact tumor progression. Despite increasing insight into their function and heterogeneity, little is known regarding the origin of CAFs. Understanding the origin of CAF heterogen...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 183 - 21
Main Authors:	Houthuijzen, Julia M., de Bruijn, Roebi, van der Burg, Eline, Drenth, Anne Paulien, Wientjens, Ellen, Filipovic, Tamara, Bullock, Esme, Brambillasca, Chiara S., Pulver, Emilia M., Nieuwland, Marja, de Rink, Iris, van Diepen, Frank, Klarenbeek, Sjoerd, Kerkhoven, Ron, Brunton, Valerie G., Scheele, Colinda L.G.J., Boelens, Mirjam C., Jonkers, Jos
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12.01.2023 Nature Publishing Group Nature Portfolio
Subjects:	13 13/106 13/31 13/51 14/19 38/91 631/67/1347 631/67/327 631/67/70 64/60 Animal models Animals Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer-Associated Fibroblasts - pathology Cell culture Cell Line, Tumor CXCL12 protein Dipeptidyl Peptidase 4 - genetics Dipeptidyl-peptidase IV Female Fibroblasts Heterogeneity Humanities and Social Sciences Humans In vivo methods and tests Inflammation Matrix metalloproteinase Matrix metalloproteinases Metalloproteinase Mice Microenvironments multidisciplinary Myeloid cells Myofibroblasts - pathology Science Science (multidisciplinary) Subpopulations Transcriptomics Transplantation Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Tumor Microenvironment Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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