A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome

Developing insight into tissue-specific transcriptional mechanisms can help improve our understanding of how genetic variants exert their effects on complex traits and disease. In this study, we apply the principles of Mendelian randomization to systematically evaluate transcriptome-wide association...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 185 - 11
Main Authors:	Richardson, Tom G., Hemani, Gibran, Gaunt, Tom R., Relton, Caroline L., Davey Smith, George
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.01.2020 Nature Publishing Group Nature Portfolio
Subjects:	45/43 631/208/199 631/208/205 631/208/480 692/308 Aromatase - genetics Fibrillin-2 - genetics Gene expression Gene Expression Regulation Genetic Association Studies Genetic diversity Genetic Predisposition to Disease Genetic variance Genetic Variation Humanities and Social Sciences Humans Hydroxymethylglutaryl CoA Reductases - genetics Mendelian Randomization Analysis multidisciplinary Multifactorial Inheritance Phenomics Phenotype Phenotypes Polymorphism, Single Nucleotide Quantitative Trait Loci Randomization Regulatory mechanisms (biology) Ribosomal Proteins - genetics Science Science (multidisciplinary) Thyroid Diseases - genetics Thyroid Diseases - metabolism Tissues Transcription Transcriptome
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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