Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb

Myocardial ischemia is one of the leading health problems worldwide. Therapy consists of the restitution of coronary perfusion which is followed by myocardial inflammation. Platelet–neutrophil interaction is a crucial process during inflammation, yet its consequences are not fully understood. Here,...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 1315 - 12
Main Authors:	Köhler, David, Granja, Tiago, Volz, Julia, Koeppen, Michael, Langer, Harald F., Hansmann, Georg, Legchenko, Ekaterina, Geisler, Tobias, Bakchoul, Tamam, Eggstein, Claudia, Häberle, Helene A., Nieswandt, Bernhard, Rosenberger, Peter
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.03.2020 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/31 14/63 59/36 59/5 64/60 692/4019/592/1339 692/4019/592/75/2/1674 692/420/256/2516 82/51 82/80 96/106 96/2 Adolescent Adult Aged Aged, 80 and over Animals Antibodies Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Axon guidance Blood platelets Blood Platelets - immunology Blood Platelets - metabolism Complex formation Coronary Vessels - pathology Disease Models, Animal Erythrocytes Erythrocytes - immunology Erythrocytes - metabolism Female Genetic modification Glycoproteins GPI-Linked Proteins - genetics GPI-Linked Proteins - immunology GPI-Linked Proteins - metabolism Health problems Humanities and Social Sciences Humans Inflammation Injuries Ischemia Male Mice Mice, Knockout Middle Aged multidisciplinary Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - immunology Myocardial Infarction - pathology Myocardial ischemia Myocardial Reperfusion Injury - blood Myocardial Reperfusion Injury - immunology Myocardial Reperfusion Injury - pathology Myocardium - pathology Neutrophils Perfusion Platelet Glycoprotein GPIb-IX Complex - metabolism Platelets Prospective Studies Reperfusion Science Science (multidisciplinary) Semaphorins - genetics Semaphorins - immunology Semaphorins - metabolism Thrombosis - immunology Thrombosis - pathology Young Adult
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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