The co-evolution of the genome and epigenome in colorectal cancer

Colorectal malignancies are a leading cause of cancer-related death 1 and have undergone extensive genomic study 2 , 3 . However, DNA mutations alone do not fully explain malignant transformation 4 – 7 . Here we investigate the co-evolution of the genome and epigenome of colorectal tumours at single...

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Bibliographic Details
Published in:	Nature (London) Vol. 611; no. 7937; pp. 733 - 743
Main Authors:	Heide, Timon, Househam, Jacob, Cresswell, George D., Spiteri, Inmaculada, Lynn, Claire, Mossner, Maximilian, Kimberley, Chris, Fernandez-Mateos, Javier, Chen, Bingjie, Zapata, Luis, James, Chela, Barozzi, Iros, Chkhaidze, Ketevan, Nichol, Daniel, Gunasri, Vinaya, Berner, Alison, Schmidt, Melissa, Lakatos, Eszter, Baker, Ann-Marie, Costa, Helena, Mitchinson, Miriam, Piazza, Rocco, Jansen, Marnix, Caravagna, Giulio, Ramazzotti, Daniele, Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Graham, Trevor A., Sottoriva, Andrea
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24.11.2022 Nature Publishing Group
Subjects:	45 45/23 631/114 631/208/177 631/67/2329 631/67/69 692/699/67/1504/1885 Accessibility Adenoma - genetics Adenoma - pathology Biological evolution Cancer Cell growth Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Chromatin Chromatin - genetics Chromatin - metabolism Cloning Coevolution Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Datasets Deoxyribonucleic acid DNA DNA methylation Epigenetics Epigenome - genetics Evolution Evolution & development Genes Genome, Human - genetics Genomes Heterogeneity Humanities and Social Sciences Humans Interferon Interferons Malignancy multidisciplinary Mutation Oncogenes - genetics Patients Positive selection Regulatory sequences Science Science (multidisciplinary) Signature analysis Transcription factors Transcription Factors - metabolism Transcriptomes Tumorigenesis Tumors
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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