Cell cycle regulation: p53-p21-RB signaling

The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both proteins play central roles in regulating the cell division cycle. RB forms complexes with the E2F family of transcription factors and downregul...

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Vydáno v:	Cell death and differentiation Ročník 29; číslo 5; s. 946 - 960
Hlavní autor:	Engeland, Kurt
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.05.2022
Témata:	Binding sites Cancer CDKN1A gene Cell cycle Cell Cycle - genetics Cell Cycle Checkpoints - genetics Cell Cycle Proteins - metabolism Cell division Cyclin A Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-dependent kinase inhibitor p27 Cyclin-dependent kinases Deoxyribonucleic acid DNA DNA damage E2F protein E2F Transcription Factors - genetics E2F Transcription Factors - metabolism Enzyme inhibitors Gene silencing Genes GTP-binding protein Kinases p53 Protein Phosphorylation Regulation Retina Retinoblastoma Retinoblastoma protein Signal Transduction Skp2 protein Transcription factors Transcription Factors - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
ISSN:	1350-9047, 1476-5403, 1476-5403
On-line přístup:	Získat plný text
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