Advanced glycation end-products, cardiac function and heart failure in the general population: The Rotterdam Study

Aims/hypothesis The aim of this work was to assess the association of advanced glycation end-products (AGEs), measured by skin autofluorescence (SAF), with prevalent heart failure, and with systolic and diastolic cardiac function, in a large population-based cohort study. Methods We assessed the cro...

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Vydané v:Diabetologia Ročník 66; číslo 3; s. 472 - 481
Hlavní autori: Arshi, Banafsheh, Chen, Jinluan, Ikram, M. Arfan, Zillikens, M. Carola, Kavousi, Maryam
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2023
Springer Nature B.V
Predmet:
Advanced glycosylation end products
Biomarkers - analysis
Cardiac function
Cardiovascular diseases
Cohort Studies
Congestive heart failure
Cross-Sectional Studies
Diabetes
Diabetes Mellitus
Glycation End Products, Advanced
Glycosylation
Heart failure
Heart Failure - epidemiology
Human Physiology
Humans
Internal Medicine
Maillard Reaction
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Population studies
Risk factors
Skin
Ventricle
Netherlands
Heart failure
Skin autofluorescence
Left ventricular diastolic function
Advanced glycation end-products
Cardiac function
Sex differences
Left ventricular systolic function
Diabetes
ISSN:0012-186X, 1432-0428, 1432-0428
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Shrnutí:Aims/hypothesis The aim of this work was to assess the association of advanced glycation end-products (AGEs), measured by skin autofluorescence (SAF), with prevalent heart failure, and with systolic and diastolic cardiac function, in a large population-based cohort study. Methods We assessed the cross-sectional association between SAF and prevalent heart failure among 2426 participants from the population-based Rotterdam Study, using logistic regression. Next, among individuals free of heart failure ( N =2362), we examined the link between SAF (on a continuous scale) and echocardiographic parameters of left ventricular (LV) systolic and diastolic function using linear regressions. Analyses were adjusted for traditional cardiovascular risk factors. Results Higher levels of SAF were associated with higher odds of prevalent heart failure (multivariable adjusted OR 2.90 [95% CI 1.80, 4.62] for one unit higher SAF value). Among individuals without heart failure, one unit increase in SAF was associated with 0.98% lower LV ejection fraction (mean difference [β] −0.98% [95% CI −1.45%, −0.50%]). The association was stronger among participants with diabetes (β −1.84% [95% CI −3.10%, −0.58%] and β −0.78% [95% CI −1.29%, −0.27%] among participants with and without diabetes, respectively). Associations of SAF with diastolic function parameters were not apparent, except in men with diabetes. Conclusions/interpretation AGE accumulation was independently associated with prevalent heart failure. Among individuals free of heart failure, AGEs were associated with cardiac function, in particular systolic function. This association was present in participants with and without diabetes and was more prominent in those with diabetes. Graphical abstract
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0012-186X
1432-0428
1432-0428
DOI:10.1007/s00125-022-05821-3