Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma

The aim of this study was to investigate the relationship between glaucoma severity and perifoveal vessel density (pfVD), branching complexity, and foveal avascular zone (FAZ) size in normal tension glaucoma (NTG). 31 patients with NTG washed out of glaucoma medications were subjected to tests inclu...

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Veröffentlicht in:Scientific reports Jg. 11; H. 1; S. 1056 - 9
Hauptverfasser: Cheng, Kelvin K. W., Tan, Beatrice L., Brown, Lyndsay, Gray, Calum, Bianchi, Eleonora, Dhillon, Baljean, MacGillivray, Tom, Tatham, Andrew J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 13.01.2021
Nature Publishing Group
Nature Portfolio
Schlagworte:
631/114/1564
631/114/794
692/53/2421
Aged
Angiography
Biomarkers
Eye
Female
Fovea Centralis - diagnostic imaging
Fovea Centralis - pathology
Glaucoma
Humanities and Social Sciences
Humans
Hypertension
Intraocular Pressure
Low Tension Glaucoma - diagnostic imaging
Low Tension Glaucoma - pathology
Macula Lutea - blood supply
Macula Lutea - diagnostic imaging
Macula Lutea - pathology
Male
multidisciplinary
Pressure measurement
Prospective Studies
Retinal Neurons - pathology
Science
Science (multidisciplinary)
Tomography, Optical Coherence
Visual field
ISSN:2045-2322, 2045-2322
Online-Zugang:Volltext
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Zusammenfassung:The aim of this study was to investigate the relationship between glaucoma severity and perifoveal vessel density (pfVD), branching complexity, and foveal avascular zone (FAZ) size in normal tension glaucoma (NTG). 31 patients with NTG washed out of glaucoma medications were subjected to tests including; intraocular pressure measurement; standard automated perimetry; optical coherence tomography (OCT) measurement of macular ganglion cell complex (mGCC), inner macular thickness (IMT) and circumpapillary retinal nerve fibre layer (cpRNFL); and OCT angiography measurement of pfVD, FAZ perimeter and multispectral fractal dimensions (MSFD). Eyes with more severe glaucoma had significantly thinner mGCC and cpRNFL and lower pfVD. MD decreased by 0.4 dB (95% CI 0.1 to 0.6 dB, P  = 0.007) for every 1% decrease in pfVD. Lower MSFD was observed in eyes with lower pfVD and in patients with systemic hypertension. Multivariable analysis, accounting for age and OCTA quality, found lower pfVD remained significantly associated with thinner IMT, thinner mGCC and worse MD but not with MSFD. pfVD was reduced in NTG and was diminished in eyes with worse MD. Macular vessel branching complexity was not related to severity of visual field loss but was lower in patients with systemic hypertension.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-80080-z