A QSP model of prostate cancer immunotherapy to identify effective combination therapies

Immunotherapy, by enhancing the endogenous anti-tumor immune responses, is showing promising results for the treatment of numerous cancers refractory to conventional therapies. However, its effectiveness for advanced castration-resistant prostate cancer remains unsatisfactory and new therapeutic str...

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Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; p. 9063
Main Authors:	Coletti, Roberta, Leonardelli, Lorena, Parolo, Silvia, Marchetti, Luca
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.06.2020 Nature Publishing Group
Subjects:	119/118 631/114/2397 631/553/2700 631/67/1059/2325 631/67/589/466 692/4028/67/589/466 Animal models Animals Cancer immunotherapy Cancer therapies Cancer vaccines Cancer Vaccines - immunology Castration Cell Line, Tumor Combined Modality Therapy - methods Combined vaccines Computer applications Differential equations Drug development Humanities and Social Sciences Humans Immune checkpoint Immune response Immune system Immunologic Factors - immunology Immunotherapy Immunotherapy - methods Male Mice Models, Biological multidisciplinary Ordinary differential equations Pharmacology Prostate - immunology Prostate cancer Prostatic Neoplasms, Castration-Resistant - immunology Prostatic Neoplasms, Castration-Resistant - therapy Science Science (multidisciplinary) Synergistic effect
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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