Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues

Increased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which tissues are responsible for changes in the AC pool in plasma. The concentrations of medium- and long-chain ACs were changing during the fed-fas...

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Vydáno v:	Scientific reports Ročník 7; číslo 1; s. 17528 - 11
Hlavní autoři:	Makrecka-Kuka, Marina, Sevostjanovs, Eduards, Vilks, Karlis, Volska, Kristine, Antone, Unigunde, Kuka, Janis, Makarova, Elina, Pugovics, Osvalds, Dambrova, Maija, Liepinsh, Edgars
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 13.12.2017 Nature Publishing Group
Témata:	101/58 631/443/319/2723 631/45/287/1183 64/60 Cardiac muscle Energy resources Heart Humanities and Social Sciences Insulin Liver Mice multidisciplinary Muscles Perfusion Plasma Rodents Science Science (multidisciplinary)
ISSN:	2045-2322, 2045-2322
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Abstract	Increased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which tissues are responsible for changes in the AC pool in plasma. The concentrations of medium- and long-chain ACs were changing during the fed-fast cycle in rat heart, muscles and liver. After 60 min running exercise, AC content was increased in fasted mice muscles, but not in plasma or heart. After glucose bolus administration in fasted rats, the AC concentrations in plasma decreased after 30 min but then began to increase, while in the muscles and liver, the contents of medium- and long-chain ACs were unchanged or even increased. Only the heart showed a decrease in medium- and long-chain AC contents that was similar to that observed in plasma. In isolated rat heart, but not isolated-contracting mice muscles, the significant efflux of medium- and long-chain ACs was observed. The efflux was reduced by 40% after the addition of glucose and insulin to the perfusion solution. Overall, these results indicate that during fed-fast cycle shifting the heart determines the medium- and long-chain AC profile in plasma, due to a rapid response to the availability of circulating energy substrates.
AbstractList	Increased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which tissues are responsible for changes in the AC pool in plasma. The concentrations of medium- and long-chain ACs were changing during the fed-fast cycle in rat heart, muscles and liver. After 60 min running exercise, AC content was increased in fasted mice muscles, but not in plasma or heart. After glucose bolus administration in fasted rats, the AC concentrations in plasma decreased after 30 min but then began to increase, while in the muscles and liver, the contents of medium- and long-chain ACs were unchanged or even increased. Only the heart showed a decrease in medium- and long-chain AC contents that was similar to that observed in plasma. In isolated rat heart, but not isolated-contracting mice muscles, the significant efflux of medium- and long-chain ACs was observed. The efflux was reduced by 40% after the addition of glucose and insulin to the perfusion solution. Overall, these results indicate that during fed-fast cycle shifting the heart determines the medium- and long-chain AC profile in plasma, due to a rapid response to the availability of circulating energy substrates. Increased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which tissues are responsible for changes in the AC pool in plasma. The concentrations of medium- and long-chain ACs were changing during the fed-fast cycle in rat heart, muscles and liver. After 60 min running exercise, AC content was increased in fasted mice muscles, but not in plasma or heart. After glucose bolus administration in fasted rats, the AC concentrations in plasma decreased after 30 min but then began to increase, while in the muscles and liver, the contents of medium- and long-chain ACs were unchanged or even increased. Only the heart showed a decrease in medium- and long-chain AC contents that was similar to that observed in plasma. In isolated rat heart, but not isolated-contracting mice muscles, the significant efflux of medium- and long-chain ACs was observed. The efflux was reduced by 40% after the addition of glucose and insulin to the perfusion solution. Overall, these results indicate that during fed-fast cycle shifting the heart determines the medium- and long-chain AC profile in plasma, due to a rapid response to the availability of circulating energy substrates.Increased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which tissues are responsible for changes in the AC pool in plasma. The concentrations of medium- and long-chain ACs were changing during the fed-fast cycle in rat heart, muscles and liver. After 60 min running exercise, AC content was increased in fasted mice muscles, but not in plasma or heart. After glucose bolus administration in fasted rats, the AC concentrations in plasma decreased after 30 min but then began to increase, while in the muscles and liver, the contents of medium- and long-chain ACs were unchanged or even increased. Only the heart showed a decrease in medium- and long-chain AC contents that was similar to that observed in plasma. In isolated rat heart, but not isolated-contracting mice muscles, the significant efflux of medium- and long-chain ACs was observed. The efflux was reduced by 40% after the addition of glucose and insulin to the perfusion solution. Overall, these results indicate that during fed-fast cycle shifting the heart determines the medium- and long-chain AC profile in plasma, due to a rapid response to the availability of circulating energy substrates.
ArticleNumber	17528
Author	Vilks, Karlis Makrecka-Kuka, Marina Kuka, Janis Liepinsh, Edgars Antone, Unigunde Pugovics, Osvalds Sevostjanovs, Eduards Volska, Kristine Makarova, Elina Dambrova, Maija
Author_xml	– sequence: 1 givenname: Marina orcidid: 0000-0003-4549-1993 surname: Makrecka-Kuka fullname: Makrecka-Kuka, Marina email: makrecka@farm.osi.lv organization: Latvian Institute of Organic Synthesis, Aizkraukles Str. 21 – sequence: 2 givenname: Eduards surname: Sevostjanovs fullname: Sevostjanovs, Eduards organization: Latvian Institute of Organic Synthesis, Aizkraukles Str. 21 – sequence: 3 givenname: Karlis surname: Vilks fullname: Vilks, Karlis organization: Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, University of Latvia, Faculty of Biology, Jelgavas Str. 1 – sequence: 4 givenname: Kristine surname: Volska fullname: Volska, Kristine organization: Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga Stradins University, Faculty of Pharmacy, Dzirciema Str. 16 – sequence: 5 givenname: Unigunde surname: Antone fullname: Antone, Unigunde organization: Latvian Institute of Organic Synthesis, Aizkraukles Str. 21 – sequence: 6 givenname: Janis surname: Kuka fullname: Kuka, Janis organization: Latvian Institute of Organic Synthesis, Aizkraukles Str. 21 – sequence: 7 givenname: Elina surname: Makarova fullname: Makarova, Elina organization: Latvian Institute of Organic Synthesis, Aizkraukles Str. 21 – sequence: 8 givenname: Osvalds surname: Pugovics fullname: Pugovics, Osvalds organization: Latvian Institute of Organic Synthesis, Aizkraukles Str. 21 – sequence: 9 givenname: Maija surname: Dambrova fullname: Dambrova, Maija organization: Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga Stradins University, Faculty of Pharmacy, Dzirciema Str. 16 – sequence: 10 givenname: Edgars surname: Liepinsh fullname: Liepinsh, Edgars organization: Latvian Institute of Organic Synthesis, Aizkraukles Str. 21
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29235526$$D View this record in MEDLINE/PubMed
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Snippet	Increased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which...
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SubjectTerms	101/58 631/443/319/2723 631/45/287/1183 64/60 Cardiac muscle Energy resources Heart Humanities and Social Sciences Insulin Liver Mice multidisciplinary Muscles Perfusion Plasma Rodents Science Science (multidisciplinary)
Title	Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues
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