Coding and regulatory variants are associated with serum protein levels and disease

Circulating proteins can be used to diagnose and predict disease-related outcomes. A deep serum proteome survey recently revealed close associations between serum protein networks and common disease. In the current study, 54,469 low-frequency and common exome-array variants were compared to 4782 pro...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 481 - 11
Main Authors:	Emilsson, Valur, Gudmundsdottir, Valborg, Gudjonsson, Alexander, Jonmundsson, Thorarinn, Jonsson, Brynjolfur G., Karim, Mohd A., Ilkov, Marjan, Staley, James R., Gudmundsson, Elias F., Launer, Lenore J., Lindeman, Jan H., Morton, Nicholas M., Aspelund, Thor, Lamb, John R., Jennings, Lori L., Gudnason, Vilmundur
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.01.2022 Nature Publishing Group Nature Portfolio
Subjects:	45/43 631/208/205/2138 631/45/475 692/53/2422 82/80 Aged Arrays Biomarkers Blood Proteins - genetics Disease Disease - classification Disease - genetics Exome - genetics Female Genetic Predisposition to Disease Genotype Humanities and Social Sciences Humans Iceland Male multidisciplinary Nucleotide sequence Polymorphism, Single Nucleotide Proteins Proteome - metabolism Proteomes Science Science (multidisciplinary) Serum levels Serum proteins Iceland
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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