The NUCKS1-SKP2-p21/p27 axis controls S phase entry

Efficient entry into S phase of the cell cycle is necessary for embryonic development and tissue homoeostasis. However, unscheduled S phase entry triggers DNA damage and promotes oncogenesis, underlining the requirement for strict control. Here, we identify the NUCKS1-SKP2-p21/p27 axis as a checkpoi...

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Vydané v:	Nature communications Ročník 12; číslo 1; s. 6959 - 14
Hlavní autori:	Hume, Samuel, Grou, Claudia P., Lascaux, Pauline, D’Angiolella, Vincenzo, Legrand, Arnaud J., Ramadan, Kristijan, Dianov, Grigory L.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 29.11.2021 Nature Publishing Group Nature Portfolio
Predmet:	13 13/106 13/109 13/31 38/70 38/71 38/89 631/1647/2017 631/45 631/80/474/2073 631/80/641/2187 631/80/641/2350 82/1 82/29 A549 Cells Animals Baculoviridae - genetics Baculoviridae - metabolism Cancer Cell cycle Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Chromatin Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-Dependent Kinase Inhibitor p27 - antagonists & inhibitors Cyclin-Dependent Kinase Inhibitor p27 - genetics Cyclin-Dependent Kinase Inhibitor p27 - metabolism Damage Deoxyribonucleic acid DNA DNA Damage Embryogenesis Embryonic growth stage Gene Expression Regulation, Neoplastic Gene silencing Genomes HCT116 Cells HT29 Cells Humanities and Social Sciences Humans Mitogens multidisciplinary Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism Osteoblasts - metabolism Osteoblasts - pathology Phosphoproteins - antagonists & inhibitors Phosphoproteins - genetics Phosphoproteins - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism S phase S Phase - genetics S-Phase Kinase-Associated Proteins - antagonists & inhibitors S-Phase Kinase-Associated Proteins - genetics S-Phase Kinase-Associated Proteins - metabolism Science Science (multidisciplinary) Sf9 Cells Signal Transduction Skp2 protein Spodoptera Transcription factors Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics Tumorigenesis Ubiquitin Ubiquitin-protein ligase
ISSN:	2041-1723, 2041-1723
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