Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s disease

The proximity ligation assay (PLA) is a specific and sensitive technique for the detection of αSyn oligomers (αSyn-PLA), early and toxic species implicated in the pathogenesis of PD. We aimed to evaluate by skin biopsy the diagnostic and prognostic capacity of αSyn-PLA and small nerve fiber reductio...

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Bibliographic Details
Published in:	NPJ Parkinson's Disease Vol. 7; no. 1; pp. 119 - 11
Main Authors:	Vacchi, Elena, Senese, Camilla, Chiaro, Giacomo, Disanto, Giulio, Pinton, Sandra, Morandi, Sara, Bertaina, Ilaria, Bianco, Giovanni, Staedler, Claudio, Galati, Salvatore, Gobbi, Claudio, Kaelin-Lang, Alain, Melli, Giorgia
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.12.2021 Nature Publishing Group Nature Portfolio
Subjects:	692/53/2421 692/699/375/1718 Accuracy Ankle Biomarkers Biomedical and Life Sciences Biomedicine Biopsy Demographics Localization Longitudinal studies Monoclonal antibodies Neurology Neurosciences Parkinson's disease Pathology
ISSN:	2373-8057, 2373-8057
Online Access:	Get full text
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