Pleiotropic genetic architecture and novel loci for C-reactive protein levels

C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci,...

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Vydáno v:	Nature communications Ročník 13; číslo 1; s. 6939 - 11
Hlavní autoři:	Koskeridis, Fotios, Evangelou, Evangelos, Said, Saredo, Boyle, Joseph J., Elliott, Paul, Dehghan, Abbas, Tzoulaki, Ioanna
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 14.11.2022 Nature Publishing Group Nature Portfolio
Témata:	38 45/43 631/208/205/2138 692/308/2056 692/4017 692/699/1702/393 C-reactive protein C-Reactive Protein - genetics Gene loci Genes Genetic Loci Genetic Pleiotropy Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Glucose metabolism Health risks Humanities and Social Sciences Humans Inflammation Inflammation - genetics Lipid metabolism Lipids Mendelian Randomization Analysis Metabolic pathways Metabolism multidisciplinary Pleiotropy Polymorphism, Single Nucleotide Proteins Quality Risk analysis Risk factors Science Science (multidisciplinary) Therapeutic targets
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
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