RHOQ is induced by DLL4 and regulates angiogenesis by determining the intracellular route of the Notch intracellular domain

Angiogenesis, the formation of new blood vessels by endothelial cells, is a finely tuned process relying on the balance between promoting and repressing signalling pathways. Among these, Notch signalling is critical in ensuring appropriate response of endothelial cells to pro-angiogenic stimuli. How...

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Bibliographic Details
Published in:	Angiogenesis (London) Vol. 23; no. 3; pp. 493 - 513
Main Authors:	Bridges, Esther, Sheldon, Helen, Kleibeuker, Esther, Ramberger, Evelyn, Zois, Christos, Barnard, Alun, Harjes, Ulrike, Li, Ji-Liang, Masiero, Massimo, MacLaren, Robert, Harris, Adrian
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01.08.2020 Springer Nature B.V
Subjects:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Angiogenesis Autophagy Biomedical and Life Sciences Biomedicine Blood vessels Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cancer Research Cardiology Cell Biology Degradation Endothelial cells Guanosine triphosphatases Human Umbilical Vein Endothelial Cells - metabolism Humans Intracellular Lysosomes Neovascularization, Physiologic Notch1 protein Nuclear transport Oncology Ophthalmology Original Paper Phagocytosis Protein Domains Receptors, Notch - genetics Receptors, Notch - metabolism rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - metabolism Route selection Signal Transduction Signaling Translocation Autophagy pathway Angiogenesis DLL4 Notch1 signalling RHOQ NICD degradation
ISSN:	0969-6970, 1573-7209, 1573-7209
Online Access:	Get full text
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