Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts

We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, conducted among men and women in the United States, and previously published data from the Al...

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Vydané v:	Cancer research (Chicago, Ill.) Ročník 74; číslo 15; s. 4090
Hlavní autori:	Seow, Wei Jie, Cawthon, Richard M, Purdue, Mark P, Hu, Wei, Gao, Yu-Tang, Huang, Wen-Yi, Weinstein, Stephanie J, Ji, Bu-Tian, Virtamo, Jarmo, Hosgood, 3rd, H Dean, Bassig, Bryan A, Shu, Xiao-Ou, Cai, Qiuyin, Xiang, Yong-Bing, Min, Shen, Chow, Wong-Ho, Berndt, Sonja I, Kim, Christopher, Lim, Unhee, Albanes, Demetrius, Caporaso, Neil E, Chanock, Stephen, Zheng, Wei, Rothman, Nathaniel, Lan, Qing
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.08.2014
Predmet:	Case-Control Studies Cohort Studies DNA - blood DNA - genetics DNA, Neoplasm - blood DNA, Neoplasm - genetics Female Humans Leukocytes - metabolism Leukocytes - ultrastructure Lung Neoplasms - blood Lung Neoplasms - genetics Male Middle Aged Prospective Studies Risk Factors Telomere - genetics
ISSN:	1538-7445, 1538-7445
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Abstract	We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, conducted among men and women in the United States, and previously published data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial conducted among male smokers in Finland, and the Shanghai Women's Health Study (SWHS), which is comprised primarily of never-smokers. The pooled population included 847 cases and 847 controls matched by study, age, and sex. Leukocyte telomere length was measured by a monochrome multiplex qPCR assay. We used conditional logistic regression models to calculate ORs and their 95% confidence intervals (CI) for the association between telomere length and lung cancer risk, adjusted for age and pack-years of smoking. Longer telomere length was associated with increased lung cancer risk in the pooled analysis [OR (95% CI) by quartile: 1.00; 1.24 (0.90-1.71); 1.27 (0.91-1.78); and 1.86 (1.33-2.62); P trend = 0.000022]. Findings were consistent across the three cohorts and strongest for subjects with very long telomere length, i.e., lung cancer risks for telomere length [OR (95% CI)] in the upper half of the fourth quartile were 2.41 (1.28-4.52), 2.16 (1.11-4.23), and 3.02(1.39-6.58) for the PLCO trial, the ATBC trial, and the SWHS, respectively. In addition, the association persisted among cases diagnosed more than 6 years after blood collection and was particularly evident for female adenocarcinoma cases. Telomere length in white blood cell DNA may be a biomarker of future increased risk of lung cancer in diverse populations.
AbstractList	We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, conducted among men and women in the United States, and previously published data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial conducted among male smokers in Finland, and the Shanghai Women's Health Study (SWHS), which is comprised primarily of never-smokers. The pooled population included 847 cases and 847 controls matched by study, age, and sex. Leukocyte telomere length was measured by a monochrome multiplex qPCR assay. We used conditional logistic regression models to calculate ORs and their 95% confidence intervals (CI) for the association between telomere length and lung cancer risk, adjusted for age and pack-years of smoking. Longer telomere length was associated with increased lung cancer risk in the pooled analysis [OR (95% CI) by quartile: 1.00; 1.24 (0.90-1.71); 1.27 (0.91-1.78); and 1.86 (1.33-2.62); P trend = 0.000022]. Findings were consistent across the three cohorts and strongest for subjects with very long telomere length, i.e., lung cancer risks for telomere length [OR (95% CI)] in the upper half of the fourth quartile were 2.41 (1.28-4.52), 2.16 (1.11-4.23), and 3.02(1.39-6.58) for the PLCO trial, the ATBC trial, and the SWHS, respectively. In addition, the association persisted among cases diagnosed more than 6 years after blood collection and was particularly evident for female adenocarcinoma cases. Telomere length in white blood cell DNA may be a biomarker of future increased risk of lung cancer in diverse populations. We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, conducted among men and women in the United States, and previously published data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial conducted among male smokers in Finland, and the Shanghai Women's Health Study (SWHS), which is comprised primarily of never-smokers. The pooled population included 847 cases and 847 controls matched by study, age, and sex. Leukocyte telomere length was measured by a monochrome multiplex qPCR assay. We used conditional logistic regression models to calculate ORs and their 95% confidence intervals (CI) for the association between telomere length and lung cancer risk, adjusted for age and pack-years of smoking. Longer telomere length was associated with increased lung cancer risk in the pooled analysis [OR (95% CI) by quartile: 1.00; 1.24 (0.90-1.71); 1.27 (0.91-1.78); and 1.86 (1.33-2.62); P trend = 0.000022]. Findings were consistent across the three cohorts and strongest for subjects with very long telomere length, i.e., lung cancer risks for telomere length [OR (95% CI)] in the upper half of the fourth quartile were 2.41 (1.28-4.52), 2.16 (1.11-4.23), and 3.02(1.39-6.58) for the PLCO trial, the ATBC trial, and the SWHS, respectively. In addition, the association persisted among cases diagnosed more than 6 years after blood collection and was particularly evident for female adenocarcinoma cases. Telomere length in white blood cell DNA may be a biomarker of future increased risk of lung cancer in diverse populations.We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, conducted among men and women in the United States, and previously published data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial conducted among male smokers in Finland, and the Shanghai Women's Health Study (SWHS), which is comprised primarily of never-smokers. The pooled population included 847 cases and 847 controls matched by study, age, and sex. Leukocyte telomere length was measured by a monochrome multiplex qPCR assay. We used conditional logistic regression models to calculate ORs and their 95% confidence intervals (CI) for the association between telomere length and lung cancer risk, adjusted for age and pack-years of smoking. Longer telomere length was associated with increased lung cancer risk in the pooled analysis [OR (95% CI) by quartile: 1.00; 1.24 (0.90-1.71); 1.27 (0.91-1.78); and 1.86 (1.33-2.62); P trend = 0.000022]. Findings were consistent across the three cohorts and strongest for subjects with very long telomere length, i.e., lung cancer risks for telomere length [OR (95% CI)] in the upper half of the fourth quartile were 2.41 (1.28-4.52), 2.16 (1.11-4.23), and 3.02(1.39-6.58) for the PLCO trial, the ATBC trial, and the SWHS, respectively. In addition, the association persisted among cases diagnosed more than 6 years after blood collection and was particularly evident for female adenocarcinoma cases. Telomere length in white blood cell DNA may be a biomarker of future increased risk of lung cancer in diverse populations.
Author	Seow, Wei Jie Lim, Unhee Kim, Christopher Cawthon, Richard M Lan, Qing Cai, Qiuyin Chow, Wong-Ho Shu, Xiao-Ou Zheng, Wei Weinstein, Stephanie J Virtamo, Jarmo Hu, Wei Min, Shen Albanes, Demetrius Berndt, Sonja I Rothman, Nathaniel Huang, Wen-Yi Purdue, Mark P Bassig, Bryan A Xiang, Yong-Bing Gao, Yu-Tang Ji, Bu-Tian Caporaso, Neil E Chanock, Stephen Hosgood, 3rd, H Dean
Author_xml	– sequence: 1 givenname: Wei Jie surname: Seow fullname: Seow, Wei Jie email: weijie.seow2@nih.gov organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland; weijie.seow2@nih.gov – sequence: 2 givenname: Richard M surname: Cawthon fullname: Cawthon, Richard M organization: Department of Human Genetics, University of Utah, Salt Lake City, Utah – sequence: 3 givenname: Mark P surname: Purdue fullname: Purdue, Mark P organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 4 givenname: Wei surname: Hu fullname: Hu, Wei organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 5 givenname: Yu-Tang surname: Gao fullname: Gao, Yu-Tang organization: Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine – sequence: 6 givenname: Wen-Yi surname: Huang fullname: Huang, Wen-Yi organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 7 givenname: Stephanie J surname: Weinstein fullname: Weinstein, Stephanie J organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 8 givenname: Bu-Tian surname: Ji fullname: Ji, Bu-Tian organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 9 givenname: Jarmo surname: Virtamo fullname: Virtamo, Jarmo organization: Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland – sequence: 10 givenname: H Dean surname: Hosgood, 3rd fullname: Hosgood, 3rd, H Dean organization: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York – sequence: 11 givenname: Bryan A surname: Bassig fullname: Bassig, Bryan A organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 12 givenname: Xiao-Ou surname: Shu fullname: Shu, Xiao-Ou organization: Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee – sequence: 13 givenname: Qiuyin surname: Cai fullname: Cai, Qiuyin organization: Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee – sequence: 14 givenname: Yong-Bing surname: Xiang fullname: Xiang, Yong-Bing organization: Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China; and – sequence: 15 givenname: Shen surname: Min fullname: Min, Shen organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 16 givenname: Wong-Ho surname: Chow fullname: Chow, Wong-Ho organization: Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas – sequence: 17 givenname: Sonja I surname: Berndt fullname: Berndt, Sonja I organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 18 givenname: Christopher surname: Kim fullname: Kim, Christopher organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 19 givenname: Unhee surname: Lim fullname: Lim, Unhee organization: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii – sequence: 20 givenname: Demetrius surname: Albanes fullname: Albanes, Demetrius organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 21 givenname: Neil E surname: Caporaso fullname: Caporaso, Neil E organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 22 givenname: Stephen surname: Chanock fullname: Chanock, Stephen organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 23 givenname: Wei surname: Zheng fullname: Zheng, Wei organization: Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee – sequence: 24 givenname: Nathaniel surname: Rothman fullname: Rothman, Nathaniel organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland – sequence: 25 givenname: Qing surname: Lan fullname: Lan, Qing organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland
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SubjectTerms	Case-Control Studies Cohort Studies DNA - blood DNA - genetics DNA, Neoplasm - blood DNA, Neoplasm - genetics Female Humans Leukocytes - metabolism Leukocytes - ultrastructure Lung Neoplasms - blood Lung Neoplasms - genetics Male Middle Aged Prospective Studies Risk Factors Telomere - genetics
Title	Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts
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