Ordered and deterministic cancer genome evolution after p53 loss

Although p53 inactivation promotes genomic instability 1 and presents a route to malignancy for more than half of all human cancers 2 , 3 , the patterns through which heterogenous TP53 (encoding human p53) mutant genomes emerge and influence tumorigenesis remain poorly understood. Here, in a mouse m...

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Veröffentlicht in:	Nature (London) Jg. 608; H. 7924; S. 795 - 802
Hauptverfasser:	Baslan, Timour, Morris, John P., Zhao, Zhen, Reyes, Jose, Ho, Yu-Jui, Tsanov, Kaloyan M., Bermeo, Jonathan, Tian, Sha, Zhang, Sean, Askan, Gokce, Yavas, Aslihan, Lecomte, Nicolas, Erakky, Amanda, Varghese, Anna M., Zhang, Amy, Kendall, Jude, Ghiban, Elena, Chorbadjiev, Lubomir, Wu, Jie, Dimitrova, Nevenka, Chadalavada, Kalyani, Nanjangud, Gouri J., Bandlamudi, Chaitanya, Gong, Yixiao, Donoghue, Mark T. A., Socci, Nicholas D., Krasnitz, Alex, Notta, Faiyaz, Leach, Steve D., Iacobuzio-Donahue, Christine A., Lowe, Scott W.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 25.08.2022 Nature Publishing Group
Schlagworte:	13/1 13/106 13/31 13/51 14/19 14/32 14/63 45/23 45/29 45/77 59/57 631/67/68 631/67/69 64/60 Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Animals Cancer Carcinogenesis - genetics Carcinogenesis - pathology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Cell cycle Deactivation Disease Progression Evolution Evolution, Molecular Gene Deletion Gene sequencing Genes, p53 - genetics Genome - genetics Genomes Genomics Genotyping Heterogeneity Heterozygosity Humanities and Social Sciences Inactivation Loss of Heterozygosity Malignancy Mice Models, Genetic multidisciplinary Mutants Mutation p53 Protein Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Science Science (multidisciplinary) Stem cells Tumor Suppressor Protein p53 - genetics Tumorigenesis Tumors
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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