Abnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland

Diabetes is undiagnosed disease and easy screening tools for it are warranted. Because foot complications are usual in diabetes, we aimed to test hypothesis that skin abnormalities are found already from patients who are not aware of having diabetes, by studying the possible association between unhe...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Scientific reports Ročník 7; číslo 1; s. 9125 - 8
Hlavní autoři: Sinikumpu, Suvi-Päivikki, Auvinen, Juha, Jokelainen, Jari, Huilaja, Laura, Puukka, Katri, Ruokonen, Aimo, Keinänen-Kiukaanniemi, Sirkka, Tasanen, Kaisa, Timonen, Markku
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 22.08.2017
Nature Publishing Group
Nature Portfolio
Témata:
14/56
692/163/2743/137/138
692/163/2743/137/773
692/1807/1812
692/699/4033
Cross-sectional studies
Diabetes
Diabetes mellitus
Feet
Glucose
Glucose metabolism
Glucose tolerance
Hemoglobin
Humanities and Social Sciences
Metabolism
multidisciplinary
Science
Science (multidisciplinary)
Skin
Skin tests
Toe
Finland
ISSN:2045-2322, 2045-2322
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Diabetes is undiagnosed disease and easy screening tools for it are warranted. Because foot complications are usual in diabetes, we aimed to test hypothesis that skin abnormalities are found already from patients who are not aware of having diabetes, by studying the possible association between unhealthy toe web skin and abnormal glucose metabolism. 1,849 cases without previously diagnosed diabetes participated to the 46-year follow-up study of the Northern Finland Birth Cohort. A skin investigation was performed for all, and abnormal skin findings in toe web spaces were taken as explanatory variables. Abnormal glucose tolerance was the main outcome and it was tested with an oral glucose tolerance test (OGTT), glycosylated haemoglobin fraction (HbA 1c ) Values are numbers (percentages) of sub and fasting blood glucose. The participants who had any abnormal skin findings in toe webs were associated with 2.5-fold (OR 2.5, 95% CI 1.3–4.9) and 6-fold (OR 6.2, 1.4–27.6) increased risk of having previously undiagnosed diabetes detected by a 2-hour OGTT and HbA 1c , respectively. The predictive power of toe web findings was comparable with FINDRISC score. Abnormal skin findings in the toe webs show increased risk of occult diabetes, and may, thus serve as an additional sign of undiagnosed diabetes.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-09354-3