Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) to the control of EE. Selective antagonism of peripheral Y1R, via the non-brain penetrable antagonist BIBO3304, leads to...

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Veröffentlicht in:	Nature communications Jg. 12; H. 1; S. 2622 - 20
Hauptverfasser:	Yan, Chenxu, Zeng, Tianshu, Lee, Kailun, Nobis, Max, Loh, Kim, Gou, Luoning, Xia, Zefeng, Gao, Zhongmin, Bensellam, Mohammed, Hughes, Will, Lau, Jackie, Zhang, Lei, Ip, Chi Kin, Enriquez, Ronaldo, Gao, Hanyu, Wang, Qiao-Ping, Wu, Qi, Haigh, Jody J., Laybutt, D. Ross, Timpson, Paul, Herzog, Herbert, Shi, Yan-Chuan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 11.05.2021 Nature Publishing Group Nature Portfolio
Schlagworte:	13/106 14/33 14/69 38 38/77 38/88 38/90 59 631/378/1488/393 64/110 692/163/2743/393 82/51 82/80 96/63 Ablation Adipocytes Adipose tissue Adipose tissue (brown) AKT protein Body fat Body weight Body weight gain Browning Diet Energy balance Energy expenditure Food intake Glucose Glucose metabolism Homeostasis Humanities and Social Sciences multidisciplinary Neuropeptide Y Obesity Receptors Science Science (multidisciplinary) Signal transduction Signaling Thermogenesis
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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