Revisiting the therapeutic potential of gingerols against different pharmacological activities

The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer’s disease, and cancer. Ginger rh...

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Published in:Naunyn-Schmiedeberg's archives of pharmacology Vol. 396; no. 4; pp. 633 - 647
Main Authors: Sharma, Samridhi, Shukla, Monu Kumar, Sharma, Krishan Chander, Tirath, Kumar, Lokender, Anal, Jasha Momo H., Upadhyay, Santosh Kumar, Bhattacharyya, Sanjib, Kumar, Deepak
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2023
Springer Nature B.V
Subjects:
Alzheimer's disease
Antioxidants
Apoptosis
Archives & records
Arthritis
Biomedical and Life Sciences
Biomedicine
Cancer
Catechols - pharmacology
Catechols - therapeutic use
Cell cycle
Cell division
Chronic pain
Diabetes mellitus
Essential oils
Fatty Alcohols - chemistry
Fatty Alcohols - pharmacology
Fatty Alcohols - therapeutic use
Flavors
Menstruation
Metabolic disorders
Nausea
Neurodegenerative diseases
Neurosciences
Osteoarthritis
Pharmaceutical sciences
Pharmacology
Pharmacology/Toxicology
Phenolic compounds
Plant Extracts - chemistry
Resins
Review
Rheumatoid arthritis
Rhizomes
Zingiber officinale - chemistry
Zingiber officinale - metabolism
Inflammation
Ginger
Gingerol
Volatile oil
Resins
Cancer
Zingiber officinale
ISSN:0028-1298, 1432-1912, 1432-1912
Online Access:Get full text
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Summary:The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer’s disease, and cancer. Ginger rhizome contains volatile oils, phenolic compounds and resins, and characterization studies showed that [6]-gingerol, [6]-shogaol, and [6]-paradol are reported to be the pharmacologically active components. Gingerol is a major chemical constituent found as volatile oil in the rhizomes of ginger. It has several medicinal benefits and used for the treatment of rheumatoid arthritis, nausea, cancer, and diabetes. Many studies have been carried out in various parts of the world to isolate and standardize gingerol for their use as a complementary medicine. The present review summarizes wide range of research studies on gingerol and its pharmacological roles in various metabolic diseases. Graphical Abstract
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ISSN:0028-1298
1432-1912
1432-1912
DOI:10.1007/s00210-022-02372-7