Revisiting the therapeutic potential of gingerols against different pharmacological activities

The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer’s disease, and cancer. Ginger rh...

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Published in:Naunyn-Schmiedeberg's archives of pharmacology Vol. 396; no. 4; pp. 633 - 647
Main Authors: Sharma, Samridhi, Shukla, Monu Kumar, Sharma, Krishan Chander, Tirath, Kumar, Lokender, Anal, Jasha Momo H., Upadhyay, Santosh Kumar, Bhattacharyya, Sanjib, Kumar, Deepak
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2023
Springer Nature B.V
Subjects:
Alzheimer's disease
Antioxidants
Apoptosis
Archives & records
Arthritis
Biomedical and Life Sciences
Biomedicine
Cancer
Catechols - pharmacology
Catechols - therapeutic use
Cell cycle
Cell division
Chronic pain
Diabetes mellitus
Essential oils
Fatty Alcohols - chemistry
Fatty Alcohols - pharmacology
Fatty Alcohols - therapeutic use
Flavors
Menstruation
Metabolic disorders
Nausea
Neurodegenerative diseases
Neurosciences
Osteoarthritis
Pharmaceutical sciences
Pharmacology
Pharmacology/Toxicology
Phenolic compounds
Plant Extracts - chemistry
Resins
Review
Rheumatoid arthritis
Rhizomes
Zingiber officinale - chemistry
Zingiber officinale - metabolism
Inflammation
Ginger
Gingerol
Volatile oil
Resins
Cancer
Zingiber officinale
ISSN:0028-1298, 1432-1912, 1432-1912
Online Access:Get full text
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Abstract The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer’s disease, and cancer. Ginger rhizome contains volatile oils, phenolic compounds and resins, and characterization studies showed that [6]-gingerol, [6]-shogaol, and [6]-paradol are reported to be the pharmacologically active components. Gingerol is a major chemical constituent found as volatile oil in the rhizomes of ginger. It has several medicinal benefits and used for the treatment of rheumatoid arthritis, nausea, cancer, and diabetes. Many studies have been carried out in various parts of the world to isolate and standardize gingerol for their use as a complementary medicine. The present review summarizes wide range of research studies on gingerol and its pharmacological roles in various metabolic diseases. Graphical Abstract
AbstractList The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer's disease, and cancer. Ginger rhizome contains volatile oils, phenolic compounds and resins, and characterization studies showed that [6]-gingerol, [6]-shogaol, and [6]-paradol are reported to be the pharmacologically active components. Gingerol is a major chemical constituent found as volatile oil in the rhizomes of ginger. It has several medicinal benefits and used for the treatment of rheumatoid arthritis, nausea, cancer, and diabetes. Many studies have been carried out in various parts of the world to isolate and standardize gingerol for their use as a complementary medicine. The present review summarizes wide range of research studies on gingerol and its pharmacological roles in various metabolic diseases.The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer's disease, and cancer. Ginger rhizome contains volatile oils, phenolic compounds and resins, and characterization studies showed that [6]-gingerol, [6]-shogaol, and [6]-paradol are reported to be the pharmacologically active components. Gingerol is a major chemical constituent found as volatile oil in the rhizomes of ginger. It has several medicinal benefits and used for the treatment of rheumatoid arthritis, nausea, cancer, and diabetes. Many studies have been carried out in various parts of the world to isolate and standardize gingerol for their use as a complementary medicine. The present review summarizes wide range of research studies on gingerol and its pharmacological roles in various metabolic diseases.
The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer’s disease, and cancer. Ginger rhizome contains volatile oils, phenolic compounds and resins, and characterization studies showed that [6]-gingerol, [6]-shogaol, and [6]-paradol are reported to be the pharmacologically active components. Gingerol is a major chemical constituent found as volatile oil in the rhizomes of ginger. It has several medicinal benefits and used for the treatment of rheumatoid arthritis, nausea, cancer, and diabetes. Many studies have been carried out in various parts of the world to isolate and standardize gingerol for their use as a complementary medicine. The present review summarizes wide range of research studies on gingerol and its pharmacological roles in various metabolic diseases.
The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is used in the treatment of nausea, osteoarthritis, muscle pain, menstrual pain, chronic indigestion, Alzheimer’s disease, and cancer. Ginger rhizome contains volatile oils, phenolic compounds and resins, and characterization studies showed that [6]-gingerol, [6]-shogaol, and [6]-paradol are reported to be the pharmacologically active components. Gingerol is a major chemical constituent found as volatile oil in the rhizomes of ginger. It has several medicinal benefits and used for the treatment of rheumatoid arthritis, nausea, cancer, and diabetes. Many studies have been carried out in various parts of the world to isolate and standardize gingerol for their use as a complementary medicine. The present review summarizes wide range of research studies on gingerol and its pharmacological roles in various metabolic diseases. Graphical Abstract
Author Kumar, Lokender
Anal, Jasha Momo H.
Shukla, Monu Kumar
Sharma, Samridhi
Bhattacharyya, Sanjib
Sharma, Krishan Chander
Kumar, Deepak
Tirath
Upadhyay, Santosh Kumar
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  givenname: Monu Kumar
  surname: Shukla
  fullname: Shukla, Monu Kumar
  organization: Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University
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  givenname: Krishan Chander
  surname: Sharma
  fullname: Sharma, Krishan Chander
  organization: Department of Entomology, School of Agriculture, Shoolini University
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  surname: Tirath
  fullname: Tirath
  organization: Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University
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  givenname: Lokender
  surname: Kumar
  fullname: Kumar, Lokender
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– sequence: 9
  givenname: Deepak
  surname: Kumar
  fullname: Kumar, Deepak
  email: guptadeepak002@gmail.com
  organization: Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36585999$$D View this record in MEDLINE/PubMed
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ISSN 0028-1298
1432-1912
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Issue 4
Keywords Inflammation
Ginger
Gingerol
Volatile oil
Resins
Cancer
Zingiber officinale
Language English
License 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
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Snippet The rhizomes of ginger have been in use in many forms of traditional and alternative medicines. Besides being employed as condiment and flavoring agent, it is...
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SubjectTerms Alzheimer's disease
Antioxidants
Apoptosis
Archives & records
Arthritis
Biomedical and Life Sciences
Biomedicine
Cancer
Catechols - pharmacology
Catechols - therapeutic use
Cell cycle
Cell division
Chronic pain
Diabetes mellitus
Essential oils
Fatty Alcohols - chemistry
Fatty Alcohols - pharmacology
Fatty Alcohols - therapeutic use
Flavors
Menstruation
Metabolic disorders
Nausea
Neurodegenerative diseases
Neurosciences
Osteoarthritis
Pharmaceutical sciences
Pharmacology
Pharmacology/Toxicology
Phenolic compounds
Plant Extracts - chemistry
Resins
Review
Rheumatoid arthritis
Rhizomes
Zingiber officinale - chemistry
Zingiber officinale - metabolism
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Title Revisiting the therapeutic potential of gingerols against different pharmacological activities
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