Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features

The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and there is an urgent need to map the landscape of immunogenic and immunodominant epitopes recognized by CD8 + T cells. Here, we analyze samples from 31 patients with COVID-19 for CD8 + T cell recognition of 500 peptide...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 2593 - 14
Main Authors:	Gangaev, Anastasia, Ketelaars, Steven L. C., Isaeva, Olga I., Patiwael, Sanne, Dopler, Anna, Hoefakker, Kelly, De Biasi, Sara, Gibellini, Lara, Mussini, Cristina, Guaraldi, Giovanni, Girardis, Massimo, Ormeno, Cami M. P. Talavera, Hekking, Paul J. M., Lardy, Neubury M., Toebes, Mireille, Balderas, Robert, Schumacher, Ton N., Ovaa, Huib, Cossarizza, Andrea, Kvistborg, Pia
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.05.2021 Nature Publishing Group Nature Portfolio
Subjects:	38/1 38/91 49/31 631/250/1619/554/1834 631/250/2152 631/250/255 Adult Aged Aged, 80 and over Alleles Antigens CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell activation Cell migration Cell recognition Convalescence Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - pathology Cytokines Epitopes Epitopes, T-Lymphocyte - immunology Female Gene expression Histocompatibility antigen HLA Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Humanities and Social Sciences Humans Immune response Immunodominance Immunodominant Epitopes - chemistry Immunodominant Epitopes - immunology Immunogenicity Immunologic Memory Immunological memory Lymphocyte Activation Lymphocytes Lymphocytes T Male Memory cells Middle Aged multidisciplinary Pandemics Polyproteins - immunology SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Viral diseases Viral Proteins - immunology
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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