SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland

Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe COVID-19 vaccine uptake and SARS-CoV-2 infection in pregnant women in Scotland, using whole-population data from a national, prospective cohort. Between the start of a COVID-19 va...

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Published in:Nature medicine Vol. 28; no. 3; pp. 504 - 512
Main Authors: Stock, Sarah J., Carruthers, Jade, Calvert, Clara, Denny, Cheryl, Donaghy, Jack, Goulding, Anna, Hopcroft, Lisa E. M., Hopkins, Leanne, McLaughlin, Terry, Pan, Jiafeng, Shi, Ting, Taylor, Bob, Agrawal, Utkarsh, Auyeung, Bonnie, Katikireddi, Srinivasa Vittal, McCowan, Colin, Murray, Josie, Simpson, Colin R., Robertson, Chris, Vasileiou, Eleftheria, Sheikh, Aziz, Wood, Rachael
Format: Journal Article
Language:English
Published: New York Nature Publishing Group US 01.03.2022
Nature Publishing Group
Subjects:
692/308/174
692/699/255/2514
692/700/478/174
Biomedical and Life Sciences
Biomedicine
Birth
Births
Cancer Research
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 Testing
COVID-19 vaccines
COVID-19 Vaccines - therapeutic use
Diagnosis
Female
Humans
Immunization
Infections
Infectious Diseases
Metabolic Diseases
Molecular Medicine
Mortality
Neurosciences
Pandemics
Population
Pregnancy
Pregnancy complications
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - prevention & control
Pregnant People
Prospective Studies
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vaccination
Vaccines
Viral diseases
Womens health
United Kingdom > UK
Scotland
ISSN:1078-8956, 1546-170X, 1546-170X
Online Access:Get full text
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Summary:Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe COVID-19 vaccine uptake and SARS-CoV-2 infection in pregnant women in Scotland, using whole-population data from a national, prospective cohort. Between the start of a COVID-19 vaccine program in Scotland, on 8 December 2020 and 31 October 2021, 25,917 COVID-19 vaccinations were given to 18,457 pregnant women. Vaccine coverage was substantially lower in pregnant women than in the general female population of 18−44 years; 32.3% of women giving birth in October 2021 had two doses of vaccine compared to 77.4% in all women. The extended perinatal mortality rate for women who gave birth within 28 d of a COVID-19 diagnosis was 22.6 per 1,000 births (95% CI 12.9−38.5; pandemic background rate 5.6 per 1,000 births; 452 out of 80,456; 95% CI 5.1−6.2). Overall, 77.4% (3,833 out of 4,950; 95% CI 76.2−78.6) of SARS-CoV-2 infections, 90.9% (748 out of 823; 95% CI 88.7−92.7) of SARS-CoV-2 associated with hospital admission and 98% (102 out of 104; 95% CI 92.5−99.7) of SARS-CoV-2 associated with critical care admission, as well as all baby deaths, occurred in pregnant women who were unvaccinated at the time of COVID-19 diagnosis. Addressing low vaccine uptake rates in pregnant women is imperative to protect the health of women and babies in the ongoing pandemic. Findings from the COVID-19 in Pregnancy in Scotland (COPS) study reveals low levels of vaccination uptake by pregnant women compared to women in the general population and that not being vaccinated is associated with increased risk of severe complications of COVID-19 in pregnancy, including perinatal mortality.
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ISSN:1078-8956
1546-170X
1546-170X
DOI:10.1038/s41591-021-01666-2