Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

The levels of the thousands of metabolites in the human plasma metabolome are strongly influenced by an individual’s genetics and the composition of their diet and gut microbiome. Here, by assessing 1,183 plasma metabolites in 1,368 extensively phenotyped individuals from the Lifelines DEEP and Geno...

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Veröffentlicht in:	Nature medicine Jg. 28; H. 11; S. 2333 - 2343
Hauptverfasser:	Chen, Lianmin, Zhernakova, Daria V., Kurilshikov, Alexander, Andreu-Sánchez, Sergio, Wang, Daoming, Augustijn, Hannah E., Vich Vila, Arnau, Weersma, Rinse K., Medema, Marnix H., Netea, Mihai G., Kuipers, Folkert, Wijmenga, Cisca, Zhernakova, Alexandra, Fu, Jingyuan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.11.2022 Nature Publishing Group
Schlagworte:	631/208 631/208/212/2142 631/326/2565 692/308/174 Biomedical and Life Sciences Biomedicine Blood plasma Cancer Research Cardiovascular system Diet Feces - microbiology Gastrointestinal Microbiome - genetics Genetic diversity Genetics Genomes Humans Infectious Diseases Intestinal microflora Metabolic Diseases Metabolites Metabolome - genetics Microbiomes Microbiota - genetics Molecular Medicine Neurosciences Phenotype Plasma Plasma levels Quality assessment Randomization Sulfite Toxins
ISSN:	1078-8956, 1546-170X, 1546-170X
Online-Zugang:	Volltext
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