Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas

Primary cutaneous γδ T cell lymphomas (PCGDTLs) represent a heterogeneous group of uncommon but aggressive cancers. Herein, we perform genome-wide DNA, RNA, and T cell receptor (TCR) sequencing on 29 cutaneous γδ lymphomas. We find that PCGDTLs are not uniformly derived from Vδ2 cells. Instead, the...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 1806 - 14
Main Authors:	Daniels, Jay, Doukas, Peter G., Escala, Maria E. Martinez, Ringbloom, Kimberly G., Shih, David J. H., Yang, Jingyi, Tegtmeyer, Kyle, Park, Joonhee, Thomas, Jane J., Selli, Mehmet E., Altunbulakli, Can, Gowthaman, Ragul, Mo, Samuel H., Jothishankar, Balaji, Pease, David R., Pro, Barbara, Abdulla, Farah R., Shea, Christopher, Sahni, Nidhi, Gru, Alejandro A., Pierce, Brian G., Louissaint, Abner, Guitart, Joan, Choi, Jaehyuk
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.04.2020 Nature Publishing Group Nature Portfolio
Subjects:	13/31 45/23 45/91 631/250/1619/554/2509 692/4028/67/69 Amino Acid Sequence Antigens Antigens, CD1d - metabolism Chromatin Chromatin Assembly and Disassembly Deoxyribonucleic acid Dermis DNA DNA sequencing Epidermis Epitopes - immunology Genome, Human Genomes HEK293 Cells Humanities and Social Sciences Humans Lymph Nodes - pathology Lymphocytes Lymphocytes T Lymphoma Lymphoma, T-Cell, Cutaneous - genetics Lymphoma, T-Cell, Cutaneous - pathology MAP kinase Models, Biological multidisciplinary Mutation Mutation - genetics Myc protein Ontogeny Phenotype Principal Component Analysis Receptors Receptors, Antigen, T-Cell, gamma-delta - metabolism Ribonucleic acid RNA Science Science (multidisciplinary) Signal Transduction Skin - pathology Skin Neoplasms - genetics Skin Neoplasms - pathology T cell receptors T-cell lymphoma Transcription, Genetic Transcriptome - genetics
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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