Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient elevation of intraocu...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 3209 - 13
Main Authors:	Chen, Huihui, Cho, Kin-Sang, Vu, T. H. Khanh, Shen, Ching-Hung, Kaur, Mandeep, Chen, Guochun, Mathew, Rose, McHam, M. Lisa, Fazelat, Ahad, Lashkari, Kameran, Au, Ngan Pan Bennett, Tse, Joyce Ka Yu, Li, Yingqian, Yu, Honghua, Yang, Lanbo, Stein-Streilein, Joan, Ma, Chi Him Eddie, Woolf, Clifford J., Whary, Mark T., Jager, Martine J., Fox, James G., Chen, Jianzhu, Chen, Dong F.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.08.2018 Nature Publishing Group Nature Portfolio
Subjects:	13/21 13/31 13/51 14/19 14/28 14/63 38/88 631/250/1619/554 631/250/347 631/250/371 631/378/2613/1786 64/110 82/29 Animals Antigens Axons - pathology Blindness Degeneration Female Germ-Free Life Glaucoma Glaucoma - complications Glaucoma - immunology Glaucoma - pathology Glaucoma - physiopathology Heat shock proteins Heat-Shock Proteins - metabolism Humanities and Social Sciences Humans Infiltration Intraocular Pressure Lymphocytes Lymphocytes B Lymphocytes T Male Mice Mice, Inbred C57BL Microbiota Microflora multidisciplinary Nerve Degeneration - complications Nerve Degeneration - immunology Nerve Degeneration - pathology Nerve Degeneration - physiopathology Neurodegeneration Retina Retinal Ganglion Cells - pathology Science Science (multidisciplinary) T cell receptors T-Lymphocytes - immunology Target recognition
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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